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NIDA Notes Articles: Opioids

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Nonmedical Opioid and Heroin Use Among High School Seniors

April 2017

This study analyzed the use of use of nonmedical opioids and heroin use among 68,000 high-school seniors participating in the NIDA-funded Monitoring the Future Study between 2009 and 2013.

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Buprenorphine Benefits Waitlisted Seekers of Opioid Treatment

March 2017

In two pilot clinical trials, buprenorphine helped participants reduce their illicit opioid use and injection drug use while awaiting admission to a methadone or buprenorphine treatment program. Researchers minimized the risks for improper use or diversion of the study medication by giving it to trial participants in a computerized, tamper-proof device that dispenses one dose each day.

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Promising Advances in the Search for Safer Opioids

February 2017

New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

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Messages Shore Up Support for Making Life-Saving Anti-Overdose Medication Widely Available

October 2016

Public health messages can increase public approval for making naloxone legally available to friends and relatives of opioid users to administer if an overdose occurs.

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Study Links Medical Marijuana Dispensaries to Reduced Mortality From Opioid Overdose

May 2016

Legally protected marijuana dispensaries (LMDs) were associated with lower rates of dependence on prescription opioids, and deaths due to opioid overdose, than would have been expected based on prior trends. However, LMDs also were associated with higher rates of recreational marijuana use and increased potency of illegal marijuana.

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Dual Regimen Aims To Shorten Medication-Assisted Therapy

May 2016

Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.

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ED-Initiated Buprenorphine Outperforms Referral or SBIRT for ED Patients With Opioid Addiction

January 2016

Emergency department visits present prime opportunities to identify people with opioid addiction and provide them with onsite initiation of treatment with buprenorphine/naloxone.

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Digital Addiction Therapies Affirm Promise in Replication and Large Trial

November 2015

Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.

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Patients Addicted to Opioid Painkillers Achieve Good Results With Outpatient Detoxification

February 2015

A significant portion of individuals who are addicted to opioid painkillers may initiate and maintain abstinence with a brief but intensive outpatient detoxification treatment followed by opioid antagonist therapy using naltrexone.

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Gene Variants Reduce Opioid Risks

June 2014

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

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