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NIDA Notes Articles: Morphine

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Promising Advances in the Search for Safer Opioids

February 2017
New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

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Mu Opioid Receptors in One Brain Region Contribute to Naloxone Aversion

April 2020
Mice genetically engineered to lack mu opioid receptors in the medial habenula were less sensitive to the unpleasant effects of the opioid antagonist naloxone and showed fewer naloxone-induced withdrawal symptoms.

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