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NIDA Notes Articles: Methadone

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Variation in the Gene for the μ-Opioid Receptor May Influence Responses to Methadone

August 2017
A single nucleotide polymorphism in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.

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Study Points to Individualized Therapy for Opioid Addiction

February 2015
Trial participants who were addicted to opioid painkillers and did not inject drugs stayed in treatment longer and achieved better outcomes than those who were addicted to heroin or injected drugs.

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Gene Variants Reduce Opioid Risks

June 2014
Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

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