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NIDA Notes Articles: Cocaine

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Why Females Are More Sensitive to Cocaine

August 2017
New research demonstrates that the hormone estradiol is responsible for females’ increased sensitivity to stimulant drugs.

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Why Take a Drug That No Longer Gives Pleasure?

September 2015
In mice, a cocaine-induced imbalance in the activity of two key populations of neurons in the reward system persists for a longer period after repeated exposure to the drug. For long-term users, this change could both weaken the cocaine “high” and strengthen the compulsion to seek the drug.

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