February 2007 Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.
Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between brain cells. This article discusses the central importance of studying drugs’ effects on neurotransmission and describes some of the most common experimental methods used in this research.
Almost one-third (32 percent) of the roughly 42,000 Monitoring the Future survey respondents reported having used marijuana during their lifetime. However, abuse of many other drugs—methamphetamine, heroin, cocaine, and some prescription medications—declined.
Teen mothers on three American Indian reservations improved on several measures of parenting after participating in Family Spirit, a home-visiting intervention developed with NIDA support. At 12 months postpartum, the women’s children exhibited reduced rates of emotional difficulties predicting later drug abuse and other behavioral problems. Infants at highest risk—those whose mothers had histories of drug abuse—benefited the most.