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NIDA Notes Articles: Cocaine

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Combined Treatments Improve Dual Abstinence

October 2009
Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

October 2009
Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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United States Ranks First in Lifetime Use of Three Drugs

November 2009
Highlights the disproportionately high rate of Americans who have used cocaine at some time during their lives as compared with other nations surveyed.

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Extended Cocaine Exposure Impairs Cognitive Function in Rats

November 2009
Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

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Methadone Therapy in Prison Benefits Men a Year Out

November 2009
Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

December 2009
Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

December 2009
Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Recovery May Be Harder for Adolescents, Animal Study Suggests

December 2009
Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

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Stroop Test Identifies Patients at Risk for Treatment Dropout

April 2010
Reports on a study of cocaine abusers revealing that the Stroop test may predict which cocaine abusers are likely to drop out of therapy.

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Peer Interaction Enhances Adolescent Rats' Drug Reward

April 2010
Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.

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