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NIDA Notes Articles: Cocaine

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How Cocaine Cues Get Planted in the Brain

September 2018
An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.

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Cocaine-Induced Increase in an Immune Protein Promotes Addiction Behaviors in Mice

October 2018
Cocaine produces a portion of its rewarding effects by increasing levels of granulocyte-colony stimulating factor (G-CSF) in the brain’s reward center. Treatments that prevent G-CSF signaling in the nucleus accumbens might reduce motivation to use cocaine.

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Disruption of Serotonin Contributes to Cocaine’s Effects

February 2019
This research traced the effects of cocaine-induced disruption of serotonin regulation in the ventral pallidum and orbitofrontal cortex. The findings suggest that these effects may contribute to drug-seeking and cocaine-associated cognitive impairments.

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Transcription Factor E2F3a Mediates Cocaine’s Effects on Gene Expression and Addiction-Related Behaviors

February 2019
This study demonstrated that cocaine increases expression of the protein E2F3a in the brain’s reward system. The changes in E2F3a levels in the nucleus accumbens are tied to addiction-related behaviors and to altered gene expression.

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