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NIDA Notes Articles: Treatment Research

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Medications That Treat Opioid Addiction Do Not Impair Liver Health

December 2013
A trial of buprenorphine/naloxone (Bup/Nx) showed no evidence that the medicine was associated with liver damage. The drug gave results similar to those of methadone. The study data indicate that although most patients can be treated safely with either methadone or Bup/Nx without major concern for liver injury, clinicians are advised to continue to monitor the liver health of their patients who are on methadone or Bup/Nx therapy.

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Messages Shore Up Support for Making Life-Saving Anti-Overdose Medication Widely Available

October 2016
Public health messages can increase public approval for making naloxone legally available to friends and relatives of opioid users to administer if an overdose occurs.

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Methadone Reduces Rats' Cocaine Seeking

December 2008
Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Methadone Therapy in Prison Benefits Men a Year Out

November 2009
Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Methamphetamine Abuse Undermines Dental Health

July 2011
Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.

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Methylphenidate for Comorbid Cocaine Abuse, ADHD

October 2006
Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

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Microneedle Milestone: One Week of Transdermal Drug Delivery

March 2014
Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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Molecular Alterations of DNA Contribute to Persistence of Memory

November 2011
In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.

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More Convenient Preparations of Buprenorphine Pass Test

July 2012
Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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