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NIDA Notes Articles: Treatment Research

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AOUD Treatment in Primary Care Settings—Is it Feasible?

January 2020
Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.

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Novel Dopamine D3 Receptor Antagonist Reduces Opioid Addiction-Like Behaviors in Rats

January 2020
The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects

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α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids

December 2019
In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.

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Mindful Awareness in Body-Oriented Therapy Proves Useful in Women Treated for Substance Use Disorder

October 2019
Mindful Awareness in Body-Oriented Therapy (MABT) improved emotion regulation, reduced craving, and promoted abstinence in women with a history of trauma and emotional problems receiving outpatient treatment for substance use disorder.

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Machine Learning Applied to Brain Imaging Data Predicts Response to Cocaine Use Disorder Treatment

October 2019
This study demonstrated that functional connectivity among a large number of brain regions predicts patients’ chances of achieving abstinence in treatment for cocaine use disorder.

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Rats Prefer Social Interaction to Heroin or Methamphetamine

August 2019
This study showed that rats will forgo heroin and methamphetamine in favor of spending time with another rat. It also highlights the importance of incorporating voluntary choice between drugs and social rewards in drug addiction research.

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Methadone Maintenance Treatment During Incarceration Has Long-Term Benefits

April 2019
Prisoners who received methadone maintenance treatment (MMT) during incarceration were more likely than prisoners who did not receive MMT to engage in the treatment after being released.

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Interim Buprenorphine Alleviates Psychiatric Symptoms in Waitlisted OUD Patients

March 2019
Interim treatment with buprenorphine significantly improved the psychiatric symptoms of people awaiting comprehensive treatment for opioid use disorder (OUD). Buprenorphine treatment, even without concurrent psychosocial counseling, may help patients with no, or delayed, access to comprehensive OUD treatment.

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A Promising Alternative to Opioid Pain Medications

February 2019
An experimental compound with a dual action at two opioid receptors may provide powerful pain relief without many of opioids' harmful side effects. En Español

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Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards

October 2018
Mindfulness-Oriented Recovery Enhancement (MORE) reduces opioid misuse among chronic pain patients. MORE shifts patients' attention away from drug cues and toward cues for natural rewards.

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