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NIDA Notes Articles: Relapse and Recovery

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

December 2009
Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

December 2009
Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

December 2009
Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.

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Young Opioid Abusers Benefit From Extended Buprenorphine-Naloxone Treatment

April 2010
Reports on a study investigating the benefits of extended opioid maintenance therapy that included drug counseling and 12 weeks of therapy with buprenorphine and naloxone.

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New Tools and Strategies to Bolster Behavioral Therapy

October 2010
Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

October 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

October 2010
Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

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Intervention Improves Abstinence, Employment Among Welfare Recipients

December 2010
Reports research to study the effectiveness of an intensive case management program to aid female substance abusers who receive welfare in staying off drugs and finding employment.

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Study Supports Methadone Maintenance in Therapeutic Communities

December 2010
Describes a study that examined the effectiveness of combining two therapies for drug abuse addiction: methadone treatment and therapeutic communities, two approaches that are rarely combined.

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Incentives Promote Abstinence

December 2010
Explores research findings on the value of motivational incentives to promote and reinforce abstinence from substances of abuse and encourage healthy behaviors.

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