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NIDA Notes Articles: Relapse and Recovery

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Lofexidine May Enhance Naltrexone Efficacy

December 2008
Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Aripiprazole Prevents Rats From Resuming Cocaine Seeking

December 2008
Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

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Cocaine Locks Rats Into Unrewarding Behaviors

April 2009
Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

October 2009
Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

October 2009
Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

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Combined Treatments Improve Dual Abstinence

October 2009
Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

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Methadone Therapy in Prison Benefits Men a Year Out

November 2009
Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Report Discusses Co-Occurrence of Drug Abuse and Other Mental Disorders

December 2009
Describes an updated report on the co-occurrence, or comorbidity, of substance use disorders and other psychiatric disorders such as ADHD, schizophrenia, and depression.

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Recovery Checkup System Helps Substance Abusers Who Have Mental Disorders

December 2009
Reports on a posttreatment intervention to support recovery that may be especially beneficial for substance abusers with co-occurring mental disorders.

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Recovery May Be Harder for Adolescents, Animal Study Suggests

December 2009
Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

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