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NIDA Notes Articles: Relapse and Recovery

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Stressful Experiences Affect Likelihood of Remission of Drug Dependence, Continued Drug Use, and Relapse

February 2018
Stressful life events are associated with reductions in a person’s chances of becoming or remaining abstinent from drugs for at least 3 years.

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Cigarette Smoking Increases the Likelihood of Drug Use Relapse

May 2018
Research suggests that helping patients quit and remain abstinent from smoking may improve their chances for sustained recovery from use of other drugs.

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Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT

June 2018
A clinical trial found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they maintained this advantage through a 6-month follow-up.

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Methadone Maintenance Treatment During Incarceration Has Long-Term Benefits

April 2019
Prisoners who received methadone maintenance treatment (MMT) during incarceration were more likely than prisoners who did not receive MMT to engage in the treatment after being released.

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Nerve-Cell Growth During Abstinence From Methamphetamine May Promote Reinstatement of Drug Use in Rats

November 2019
Neurogenesis that occurs during abstinence from methamphetamine in a brain region related to memory and learning may promote relapse-like behavior.

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α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids

December 2019
In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.

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