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NIDA Notes Articles: Medication Development

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Selenium Shows Promise as an Adjunct Therapy for HIV

December 2008
Reports on a randomized controlled trial of HIV-infected men and women who, as a result of receiving selenium supplements, experienced lower HIV viral load and greater CD4 cell count.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008
Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Basic Science Discoveries Yield Novel Approaches to Analgesia

September 2008
Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

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Naltrexone-Nicotine Patch Combination Shows Promise

April 2007
Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

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Vaccine May Reduce Fetal Exposure to Nicotine

April 2007
Describes research on a vaccine developed to facilitate smoking cessation by blocking nicotine penetration into the brain.

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