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NIDA Notes Articles: Medication Development

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Potential Pain Medication Targets Peripheral Nerves

September 2012
Researchers report a significant advance in the search for medications that can suppress pain but avoid opioids’ abuse potential and other undesirable CNS effects. A new compound reduces mouse responses in animal models of neurogenic and chronic inflammatory (e.g., arthritic) pain. The compound, called UB937, enhances the natural pain-killing activity of the neurotransmitter anandamide, and exerts its analgesic effects entirely in peripheral tissues, without entering the brain.

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Oxycodone Vaccine Passes Early Tests

May 2013
A new vaccine hindered the often-abused prescription opioids oxycodone and hydrocodone from entering the brain and suppressed one of the drugs’ signature central nervous system effects. The findings warrant continued development of the vaccine as a potential aid in the treatment of oxycodone and hydrocodone abuse and dependence.

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NIDA Appoints New Director of the Intramural Research Program

December 2010
Announces NIDA’s new director of its intramural research program, Antonello Bonci, M.D., a leading researcher in neuropsychopharmacology.

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NIDA Announces Avant-Garde Medication Development Awards

March 2012
Dr. Thomas Kosten of Baylor College of Medicine and Dr. Peter Burkhard of the University of Connecticut are the recipients of NIDA’s 2011 Avant-Garde Awards for Innovative Medication Development Research. Dr. Kosten is developing a vaccine against methamphetamine abuse and Dr. Burkhard is developing a vaccine to counter nicotine addiction.

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New Vaccines Are Being Developed Against Addiction and Relapse

December 2008
Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

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New Tools and Strategies to Bolster Behavioral Therapy

October 2010
Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

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Neuropeptide Promotes Behaviors Tied to Addiction and Overeating

July 2011
Reports on several studies implicating a certain neuropeptide (a signaling molecule) in fostering addition and overeating and discusses implications for addiction treatment.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction, Part 2

April 2016
When lobeline turned out not to be the answer, it became a starting point. Dr. Linda Dwoskin and her team set out to transform the molecule into something more effective and with fewer side effects.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction

January 2015
This is the first in a series of NIDA Notes articles that will follow a team of researchers seeking a medication for methamphetamine addiction. This installment describes the early promise of the compound lobeline and the new directions the team discovered in studying it.

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Naltrexone-Nicotine Patch Combination Shows Promise

April 2007
Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

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