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NIDA Notes Articles: Medication Development

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Dr. Kevin M. Gray Q & A: A Potential Medication for Marijuana Dependence

October 2014
Dr. Kevin M. Gray discusses why it’s the perfect time for discovering new evidence-based treatments for marijuana dependence. In an accompanying podcast, he discusses a clinical trial that examines NAC’s potential as a treatment for marijuana dependence among adults.

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Dr. Thomas Kosten Q & A: Vaccines To Treat Addiction

June 2015
In this article and accompanying podcast, Dr. Thomas Kosten discusses the idea and current status of antidrug vaccines to treat substance use and addiction.

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Dual Regimen Aims To Shorten Medication-Assisted Therapy

May 2016
Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.

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In Animals, Opioid Combination Shows Promise for Safer Pain Relief

June 2018
In rats, the combination treatment of oxycodone/nalfurafine had lower levels of abuse liability and produced less respiratory depression than oxycodone alone.

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Microneedle Milestone: One Week of Transdermal Drug Delivery

March 2014
Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction

January 2015
This is the first in a series of NIDA Notes articles that will follow a team of researchers seeking a medication for methamphetamine addiction. This installment describes the early promise of the compound lobeline and the new directions the team discovered in studying it.

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction, Part 2

April 2016
When lobeline turned out not to be the answer, it became a starting point. Dr. Linda Dwoskin and her team set out to transform the molecule into something more effective and with fewer side effects.

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Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3

May 2018
Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first ever medication to treat methamphetamine addiction.

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Novel Compound Alleviates Hard-to-Treat Pain in Mice

June 2018
A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.

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Promising Advances in the Search for Safer Opioids

February 2017
New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

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