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NIDA Notes Articles: Infectious Diseases

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Blocking Protein Complex May Lock Down HIV Reservoirs

September 2017
Inhibiting mTOR, a regulatory protein complex, can prevent reactivation of latent HIV. Medications to inhibit mTOR might help people with HIV achieve and maintain undetectable HIV viral loads.

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New Approach Uses Immune Cells To Deliver Anti-HIV Medications

October 2014
Nano-antiretroviral therapy (nano-ART) turns macrophages—one of the very cell types that HIV uses to replicate and spread through the body—into carriers for anti-HIV medications. The approach has the potential to make treatment for HIV easier and more effective.

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Expanded HIV Screening Projected To Decrease Spread of the Virus

April 2014
Intensified screening for HIV among injection drug users receiving opioid agonist therapy could prevent more than twice as many new infections as current screening practice. A recent study based on mathematical modeling found that screening every 6 months instead of annually, and adding viral RNA testing to the currently used HIV antibody testing, could improve both effectiveness and cost-effectiveness.

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