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Your search for Pain returned 6 results. Search again.

Basic Science

Novel Dopamine D3 Receptor Antagonist Reduces Opioid Addiction-Like Behaviors in Rats

The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects

Basic Science

α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids

In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.

Treatment

A Promising Alternative to Opioid Pain Medications

An experimental compound with a dual action at two opioid receptors may provide powerful pain relief without many of opioids' harmful side effects.

Treatment

Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards

Mindfulness-Oriented Recovery Enhancement (MORE) reduces opioid misuse among chronic pain patients. MORE shifts patients' attention away from drug cues and toward cues for natural rewards.

Treatment

Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients

Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics.

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