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Treatment

Antiretroviral Therapy Combined With CRISPR Gene Editing Can Eliminate HIV Infection in Mice

This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir–targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9 out of 23 mice that received the combination treatment. HIV was not eliminated in any of the mice that were given either treatment alone.

Public Health

Integrated Intervention Benefits People Who Inject Drugs and Have HIV

In this international trial, participants who received the intervention engaged in HIV treatment, achieved viral suppression at higher rates, and died at half the rate of participants in a control group.

Basic Science

A New Tool for Investigating HIV in the Brain

Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in the brain.

Public Health

Blocking Protein Complex May Lock Down HIV Reservoirs

Inhibiting mTOR, a regulatory protein complex, can prevent reactivation of latent HIV. Medications to inhibit mTOR might help people with HIV achieve and maintain undetectable HIV viral loads.

Basic Science

Gene Variant Is Associated With Reduced HIV Transmission

A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.

NIDA Notes

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