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Your search for Opioids returned 23 results. Search again.

Basic Science

α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids

In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.

Public Health

Drug Use and Its Consequences Increase Among Middle-Aged and Older Adults

The spread of marijuana use and the opioid epidemic over the past 10 years have affected middle-aged and older Americans. In addition, prescription opioid and benzodiazepine misuse increased older adults’ risk of suicidal thoughts.

Treatment

Methadone Maintenance Treatment During Incarceration Has Long-Term Benefits

Prisoners who received methadone maintenance treatment (MMT) during incarceration were more likely than prisoners who did not receive MMT to engage in the treatment after being released.

Treatment

Interim Buprenorphine Alleviates Psychiatric Symptoms in Waitlisted OUD Patients

Interim treatment with buprenorphine significantly improved the psychiatric symptoms of people awaiting comprehensive treatment for opioid use disorder (OUD). Buprenorphine treatment, even without concurrent psychosocial counseling, may help patients with no, or delayed, access to comprehensive OUD treatment.

Treatment

A Promising Alternative to Opioid Pain Medications

An experimental compound with a dual action at two opioid receptors may provide powerful pain relief without many of opioids' harmful side effects.

Treatment

New Studies Clarify Risk Factors for Neonatal Abstinence Syndrome

A recent NIDA-sponsored study found higher rates of NAS among males than among females. A second study found that, among infants whose mothers were treated with buprenorphine while pregnant, NAS was more severe among those whose mothers used other substances.

Treatment

Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards

Mindfulness-Oriented Recovery Enhancement (MORE) reduces opioid misuse among chronic pain patients. MORE shifts patients' attention away from drug cues and toward cues for natural rewards.

Treatment

As Opioid Use Disorders Increased, Prescriptions for Treatment Did Not Keep Pace

Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to staying in treatment.

Treatment

In Animals, Opioid Combination Shows Promise for Safer Pain Relief

In rats, the combination treatment of oxycodone/nalfurafine had lower levels of abuse liability and produced less respiratory depression than oxycodone alone.

Treatment

Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients

Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics.

Treatment

Deep Brain Stimulation Attenuates Rats’ Responses to Heroin

High-frequency electrical stimulation of neurons deep in the brain can reduce rats’ relapse-like behavior and motivation to take heroin. The finding strengthens hope that deep brain stimulation might offer a new treatment alternative for opioid addiction, particularly for patients who have not benefited from other treatments.

Basic Science

Variation in the Gene for the μ-Opioid Receptor May Influence Responses to Methadone

A single nucleotide polymorphism in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.

Treatment

Opioid Agonist Treatment Reduces Societal Costs of Crime

Patients who initiate time-unlimited opioid-agonist therapy will generate lower average total crime-related costs over the next 6 months than patients who initiate a 21-day detoxification regimen.

Public Health

Nonmedical Opioid and Heroin Use Among High School Seniors

This study analyzed the use of use of nonmedical opioids and heroin use among 68,000 high-school seniors participating in the NIDA-funded Monitoring the Future Study between 2009 and 2013.

Treatment

Buprenorphine Benefits Waitlisted Seekers of Opioid Treatment

In two pilot clinical trials, buprenorphine helped participants reduce their illicit opioid use and injection drug use while awaiting admission to a methadone or buprenorphine treatment program. Researchers minimized the risks for improper use or diversion of the study medication by giving it to trial participants in a computerized, tamper-proof device that dispenses one dose each day.

Basic Science

Promising Advances in the Search for Safer Opioids

New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

Treatment

Messages Shore Up Support for Making Life-Saving Anti-Overdose Medication Widely Available

Public health messages can increase public approval for making naloxone legally available to friends and relatives of opioid users to administer if an overdose occurs.

Public Health

Study Links Medical Marijuana Dispensaries to Reduced Mortality From Opioid Overdose

Legally protected marijuana dispensaries (LMDs) were associated with lower rates of dependence on prescription opioids, and deaths due to opioid overdose, than would have been expected based on prior trends. However, LMDs also were associated with higher rates of recreational marijuana use and increased potency of illegal marijuana.

Treatment

Dual Regimen Aims To Shorten Medication-Assisted Therapy

Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.

Treatment

ED-Initiated Buprenorphine Outperforms Referral or SBIRT for ED Patients With Opioid Addiction

Emergency department visits present prime opportunities to identify people with opioid addiction and provide them with onsite initiation of treatment with buprenorphine/naloxone.

Treatment

Digital Addiction Therapies Affirm Promise in Replication and Large Trial

Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.

Treatment

Patients Addicted to Opioid Painkillers Achieve Good Results With Outpatient Detoxification

A significant portion of individuals who are addicted to opioid painkillers may initiate and maintain abstinence with a brief but intensive outpatient detoxification treatment followed by opioid antagonist therapy using naltrexone.

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