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Basic Science

Transcription Factor E2F3a Mediates Cocaine’s Effects on Gene Expression and Addiction-Related Behaviors

This study demonstrated that cocaine increases expression of the protein E2F3a in the brain’s reward system. The changes in E2F3a levels in the nucleus accumbens are tied to addiction-related behaviors and to altered gene expression.

Basic Science

How Cocaine Cues Get Planted in the Brain

An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse.

Basic Science

A New Tool for Investigating HIV in the Brain

Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in the brain.

Basic Science

A Gene Links Impulsivity and Drug Use Vulnerability

Understanding the relationships between impulsivity and drug use vulnerability may help identify new ways of treating or preventing substance use disorders.

Basic Science

Gene Variant Is Associated With Reduced HIV Transmission

A gene variant appears to partially shield people whose behaviors entail high risk for exposure to human immunodeficiency virus (HIV) from becoming infected.

Basic Science

Animal Study Suggests Marijuana May Affect Future Offspring’s Susceptibility to Heroin

Can marijuana use put offspring at heightened risk for opiate addiction, even if the use stops before the offspring are conceived? Results from a recent NIDA-funded study are consistent with other studies suggesting that a parent’s history of drug use, even preconception, may affect a child’s brain function and behavior.

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