En español

2015 Avant-Garde Awards offer extraordinary ideas in HIV/AIDS research

NIH’s awards showcase potentially transformative research on prevention, immune system, drug development, and “minibrain” models made of human tissue

February 09, 2015

Dr. Jacques Normand describes the 2015 NIDA Avant-Garde awardsDr. Jacques Normand describes the 2015 NIDA Avant-Garde awards Watch video

With proposals ranging from innovative therapies to the development of unique organoid models of the brain, five scientists have been selected to receive the 2015 Avant-Garde Award for HIV/AIDS Research from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. The five scientists will each receive $500,000 per year for five years to support their research. NIDA's annual Avant-Garde Award competition, now in its eighth year, is intended to stimulate high-impact research that may lead to groundbreaking opportunities for the prevention and treatment of HIV/AIDS in drug users.

“Despite the success of combined antiretroviral therapies in the treatment of HIV/AIDS, HIV remains a chronic disease with a host of debilitating side effects that are exacerbated in those suffering from substance use disorders,” said NIDA Director Nora D. Volkow, M.D. “These scientists have proposed creative approaches that could transform the way we think about HIV/AIDS research, and could lead to the development of exciting new tools and strategies to prevent infections and improve the lives of substance abusers infected with HIV.”

Awardees are listed below:

Don C. Des Jarlais, Ph.D.Dr. Don Des Jarlais

Don C. Des Jarlais, Ph.D.,
Mount Sinai Beth Israel, New York City

Project: Combined Prevention to Reduce Initiation into Injecting Drug Use

Dr. Des Jarlais will lead a multi-component HIV prevention intervention study in two sites with growing concerns about  heroin use — New York City and Tallinn, Estonia in Eastern Europe. Researchers will focus on combining a number of interventions with demonstrated effectiveness in reducing the number of drug users who transition to injection drugs.

“There are a number of evidence-based programs for reducing initiation into injecting drug use, including the Heroin Sniffer project, the Break the Cycle project, Couples-based HIV counseling and low threshold drug treatment,” said Des Jarlais. “This project will apply a combined prevention approach to reduce initiation into injecting drug use.”

Eli Gilboa, Ph.D.Dr. Eli Gilboa

Eli Gilboa, Ph.D.,
University of Miami School of Medicine

Project: Reversing HIV T cell Dysfunction by Aptamer Targeting of Therapeutic siRNAs

Dr. Gilboa proposes the development of novel drugs that successfully restore the function of T cells — important in immune response — and would have the potential to be therapeutically transformative for AIDS patients, including substance users in whom drugs further undermine their immune function.

“A major challenge for HIV-infected patients is that the immune system, particularly for drug abuse patients, is becoming progressively dysfunctional,” said Gilboa. “The Avant-Garde Award provides us with the unique opportunity to develop a novel nucleic acids based drug and drug delivery platform to block key intracellular pathways that mediate immune dysfunction.”

Nichole Klatt, Ph.D.Dr. Nichole Klatt

Nichole Klatt, Ph.D.,
University of Washington, Seattle

Project: Impact of Cannabis on Inflammation and Viral Persistence in Treated HIV/SIV

Dr. Klatt proposes development of HIV cure strategies by using non-psychoactive cannabinoids as potential therapeutic agents. Since cannabinoids, derivatives of cannabis, have been used to treat nausea and pain and have been shown to be anti-inflammatory in animal models, Dr. Klatt theorized that cannabinoids could be effective in reducing inflammation common in HIV patients.

 “The goal of our Avant-Garde research is to understand how cannabis may alter gastrointestinal immunity, inflammation and viral reservoirs in HIV-infected people,” said Klatt. “We want to determine the mechanisms by which cannabis exerts its effects and develop non-psychoactive cannabinoids as a potential adjunct treatment for HIV infection.”

Alan D. Levine, Ph.D.Dr. Alan Levine

Alan D. Levine, Ph.D.,
Case Western Reserve University, Cleveland

Project: Repairing the Intestinal Epithelium from the Dual Action of HIV and Drug Use

Dr. Levine will investigate the loss of intestinal barrier protection initiated by HIV infection and the resultant, systemic inflammation due to chronic exposure to gut-derived microbial products. This situation is exacerbated in the drug-abusing HIV infected population in whom drugs exert toxic effects on the gastrointestinal tract which synergize with HIV.

“It is an honor and quite humbling to be recognized via the NIDA Avant-Garde Award and to follow in the path of previous recipients who are outstanding, internationally acclaimed HIV and drug abuse investigators,” said Levine. “This award will enable us to define the molecular and cellular mechanisms that increase intestinal permeability via a loss in epithelial integrity and homeostasis, and to test the hypothesis that repairing barrier function is a novel approach to HIV- and illicit drug-promoted mucosal damage.”

Tariq M. Rana, Ph.D.Dr. Tariq Rana

Tariq M. Rana, Ph.D.,
University of California San Diego

Project: Modeling HIV/AIDS Associated Neurological Disorders with Human Pluripotent Cells

Dr. Rana will use an innovative approach to better understand the molecular mechanisms of brain disorders caused by HIV and its interaction with the damage from the use of methamphetamine. This project will build miniature models of the brain — developed with stem cells — to investigate brain injuries caused by HIV that are associated with neurocognitive disorders and the interactions with methamphetamine exposures.

“The human cerebral cortex has evolved strikingly as compared to those of other species, and no animal model accurately captures human-specific brain functions,” said Dr. Rana. “The creation of minibrains — or organoids — will permit, for the first time, study of the toxic effects of addiction and HIV on the human brain in a dish. This offers us the exciting opportunity to design patient-specific model systems, which could potentially revolutionize drug discovery and precision medicine for central nervous system disorders.”

These awardees were among the many applicants whose proposals reflect diverse scientific disciplines and approaches to HIV/AIDS research. The Avant-Garde Awards are modeled after the NIH Pioneer Awards and are granted to scientists of exceptional creativity who propose high-impact research that could open new avenues for prevention and treatment of HIV/AIDS among drug abusers.

For information about NIDA’s AIDS Research Program, including the Avant-Garde Award Program for HIV/AIDS Research, go to www.drugabuse.gov/AIDS.  Read about selected highlights of past Avant-Garde awardees.

Gilboa, Des Jarlais, Rana, Klatt and Levine are funded under grant numbers DA039560, DA039542, DA039562, DA037979 and DA037997, respectively.

NIDA Press Office

About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at www.drugabuse.gov, which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@nida.nih.gov. Online ordering is available at drugpubs.drugabuse.gov. NIDA’s media guide can be found at www.drugabuse.gov/publications/media-guide/dear-journalist, and its easy-to-read website can be found at www.easyread.drugabuse.gov. You can follow NIDA on Twitter and Facebook.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH. . .Turning Discovery Into Health®

This page was last updated February 2015

News Releases

Oct 2016

Sep 2016

Aug 2016

Jul 2016

Jun 2016

May 2016

Apr 2016

Mar 2016

Feb 2016

Jan 2016

Dec 2015

Nov 2015

Oct 2015

Sep 2015

Aug 2015

Jul 2015

Jun 2015

May 2015

Apr 2015

Mar 2015

Feb 2015

Jan 2015

Dec 2014

Nov 2014

Oct 2014

Sep 2014

Aug 2014

Jul 2014

Jun 2014

May 2014

Apr 2014

Mar 2014

Feb 2014

Jan 2014

Dec 2013

Nov 2013

Oct 2013

Sep 2013

Aug 2013

Jul 2013

Jun 2013

May 2013

Apr 2013

Mar 2013

Feb 2013

Jan 2013

Dec 2012

Nov 2012

Oct 2012

Sep 2012

Aug 2012

Jul 2012

Jun 2012

May 2012

Apr 2012

Mar 2012

Feb 2012

Jan 2012

Dec 2011

Nov 2011

Oct 2011

Sep 2011

Aug 2011

Jul 2011

Jun 2011

May 2011

Apr 2011

Mar 2011

Jan 2011

Dec 2010

Nov 2010

Sep 2010

Aug 2010

Jul 2010

May 2010

Apr 2010

Mar 2010

Jan 2010

Get this Publication

Cite this article

APA style citation

NIDA (2015). 2015 Avant-Garde Awards offer extraordinary ideas in HIV/AIDS research. Retrieved , from https://www.drugabuse.gov/news-events/news-releases/2015/02/2015-avant-garde-awards-offer-extraordinary-ideas-in-hivaids-research

press ctrl+c to copy
Receive Latest Science Articles in your Email!
You will only receive messages related to Latest Science