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Gene variant may predict whether a person will benefit from nicotine replacement therapies

Science Spotlight

November 01, 2013

Unhappy face on cigarettes

NIH-funded research shows that differences in the CYP2A6 gene -- which controls in part how fast nicotine is metabolized -- can predict whether nicotine replacement therapies (nicotine lozenge and/or nicotine patch) will be effective in helping a person quit smoking. The effectiveness of buproprion, a non-nicotine based medication often prescribed to quit smoking, was not affected by differences in this gene.

This study adds to previous findings with the CHRNA5 gene, showing that screening for genetic variation may better guide personalized treatments to quit smoking.

The study was partially funded by NIDA, NCI, NHGRI, NCATS, and NIMH. For a copy of the study, published online Sept 11, go to http://onlinelibrary.wiley.com/doi/10.1111/add.12353/abstract.

For more information, contact the NIDA press office at media@nida.nih.gov or 301-443-6245.

NIDA Press Office

About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at www.drugabuse.gov, which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@nida.nih.gov. Online ordering is available at drugpubs.drugabuse.gov. NIDA’s media guide can be found at www.drugabuse.gov/publications/media-guide/dear-journalist, and its easy-to-read website can be found at www.easyread.drugabuse.gov. You can follow NIDA on Twitter and Facebook.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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    NIDA. (2013, November 1). Gene variant may predict whether a person will benefit from nicotine replacement therapies. Retrieved from https://www.drugabuse.gov/news-events/news-releases/2013/11/gene-variant-may-predict-whether-person-will-benefit-nicotine-replacement-therapies

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