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NIDA

A look at drug craving

Science Highlight

August 28, 2018

The concept of thinking background with brainThe concept of thinking.©Shutterstock/vladguk

Studies using animal models of addiction have shown that drug seeking progressively increases after drug self-administration stops, which is a phenomenon called incubation of drug craving. Using neuroanatomical and neuropharmacological methods to measure brain activity, NIDA neuroscientists have identified a novel motivation-related thalamus-to-striatum brain projection that is critical to incubation of methamphetamine craving in the rat model. Identifying brain projections related to incubation of drug craving could provide new insights on the circuits that control drug craving and relapse.

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