Latest from NIDA

Microglia Revealed

 |  Neuroscientists at the NIDA Intramural Research Program, with colleagues from the Johns Hopkins University, conducted the most extensive analysis to date of microglia in the midbrain of healthy mice. They...

Endocannabinoid Regulates Cocaine Reward

 |  Investigators have shown that 2-AG, an endocannabinoid (i.e., a cannabinoid manufactured within the body, as opposed to plant-derived), augments the cocaine-induced dopamine surge in the brain’s reward system. The discovery...
 |  Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between neurons (nerve cells) in the brain. Many scientific studies conducted over decades...

Why Are Our Brains So Big and Powerful?

 |  Why is the human brain so much bigger and more powerful than that of other animals? Researchers have investigated the hypothesis that changes not only in our genes themselves, but...

Promising Advances in the Search for Safer Opioids

 |  Two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids...