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Links to the latest resources on COVID-19
Latest from NIDA
Serotonin Receptor Agonist Lorcaserin Reduces Relapse to Drug Use in Monkeys
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The serotonin 2C receptor agonist lorcaserin reduced reinstatement of drug-seeking behavior in response to heroin or cocaine in a nonhuman primate model of relapse.
E-Cigarette Characteristics May Influence Use and Are Potential Targets for Regulatory Policy
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People's decisions to use e-cigarettes, as well as perceptions about associated risks, are influenced by the e-cigarettes' nicotine levels and available flavors. The influence of these characteristics on decision-making and...
Study highlights effectiveness of methadone and buprenorphine
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In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related...
NIDA scientists: Blocking adenosine receptors should counteract adverse effects of cannabinoids
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Computational modeling by NIDA scientists suggests the possible use of adenosine A2A receptor antagonists to counteract the adverse effects of cannabinoids.
Babies exposed to HCV not adequately tested
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NIDA-funded science has found that HCV exposed infants might not be commonly or adequately tested.
Antiretroviral Therapy Combined With CRISPR Gene Editing Can Eliminate HIV Infection in Mice
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This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir—targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9...
Many teens who overdose on opioids do not get effective follow-up
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An analysis of Medicaid records shows that less than one-third of youths treated for a nonfatal opioid overdose received timely follow-up treatment, and only 1 in 54 youths received recommended...
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Researchers move their monoclonal antibody (mAb) into clinical trials to see if it can be an effective treatment for methamphetamine use.
Coaxing the brain to pay attention to healthier choices
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Neuroscience research from NIDA’s Intramural Research Program suggests that cortical mechanisms, especially in the orbitofrontal cortex, are likely involved in attentional bias to cocaine associated environmental cues and offer a...
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Researchers have created a monoclonal antibody (mAb) that is intended to interact with methamphetamine and decrease its ability to enter the brain.
AOUD Treatment in Primary Care Settings—Is it Feasible?
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Treatment for alcohol and opioid use disorders (AOUD) is feasible in primary care settings, but ongoing funding to support organizational capacity is critical for sustaining such programs.
Hearing on Cannabis Policies for the New Decade
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Chairwoman Eshoo, Ranking Member Burgess, and members of the Subcommittee, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH)...
A New Era at NIDA Notes
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As we enter a new year, we would like to honor and thank NIDA Notes Editor David Anderson, who recently retired after 20 years at the helm of NIDA’s signature...
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The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects
Changing the way we view opioid receptors
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Newly published research from NIDA funded scientists offers new insight into how opioid receptors work to regulate chemical communication in the brain. The researchers discover unexpected receptor mobility and diffusion...
The Strong African American Families Program Improves Lives of Rural African American Youth
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This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the...
Vaping of marijuana on the rise among teens
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Findings from the 2019 Monitoring the Future (MTF) survey demonstrate the appeal of vaping to teens, as seen in the increased prevalence of marijuana use as well as nicotine vaping.
α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids
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In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA...
National Institute on Drug Abuse to hold teleconference discussing key findings of 2019 Monitoring the Future Survey on teen drug use
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The National Institute on Drug Abuse will hold a teleconference discussing key findings of 2019 Monitoring the Future Survey on teen drug use.
Measuring the complex path to a prescription opioid use disorder
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NIDA scientists examine an accepted model of the causes of depression to determine its usefulness as a foundation to predict the probability of prescription opioid use disorder.
New discovery on the brain’s reward pathway
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Scientists at NIDA’s Intramural Research Program (IRP) have identified a population of neurons engaged in the compulsive nature of food seeking, which, like substance use, engage the brain’s reward circuit...
Nerve-Cell Growth During Abstinence From Methamphetamine May Promote Reinstatement of Drug Use in Rats
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Neurogenesis that occurs during abstinence from methamphetamine in a brain region related to memory and learning may promote relapse-like behavior.
Event registration opens for 10th anniversary of National Drug and Alcohol Facts Week®
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The National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) announced that event registration begins today for the 10th annual National Drug and...
NIH-funded study finds teens prefer mint and mango vaping flavors
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A new analysis suggests that teens prefer mint and mango as their vaping flavors of choice for e-cigarettes
Healing the altered brains of smokers
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A study from NIDA’s Intramural Research Program illuminates the roles of the brain’s striatum and habenula in nicotine withdrawal and reward, suggesting that current medications for smoking cessation are not...
Mindful Awareness in Body-Oriented Therapy Proves Useful in Women Treated for Substance Use Disorder
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Mindful Awareness in Body-Oriented Therapy (MABT) improved emotion regulation, reduced craving, and promoted abstinence in women with a history of trauma and emotional problems receiving outpatient treatment for substance use...
Who is most likely to become addicted to nicotine?
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NIDA scientists discover that connectivity between insular regions of the brain before using nicotine can predict severity of addiction.
Racial and Socioeconomic Disparities in Tobacco Smoke Exposure Persist Among U.S. Children
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The number of children (ages 3 to 11 years) in the United States who are exposed to tobacco smoke decreased steadily from 1999 to 2014. However, childhood tobacco smoke exposure...
Marijuana and America’s Health: Questions and Issues for Policy Makers
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Go to the Senate Caucus on International Narcotics Control site Chairman Cornyn, Co-Chairwoman Feinstein and members of the Caucus on International Narcotics Control, we appreciate the opportunity to share the...