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The dopamine D3 receptor antagonist VK4-116 reduced oxycodone self-administration in rats, as well as drug-seeking behaviors after oxycodone reinstatement following withdrawal. VK4-116 did not interfere with oxycodone’s pain-relieving effects
Latest from NIDA
Changing the way we view opioid receptors
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Newly published research from NIDA funded scientists offers new insight into how opioid receptors work to regulate chemical communication in the brain. The researchers discover unexpected receptor mobility and diffusion...
The Strong African American Families Program Improves Lives of Rural African American Youth
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This video highlights the Strong African American Families Program, a prevention program targeted at 10- to 14-year-old rural African American youths and their families. Numerous studies have shown that the...
Vaping of marijuana on the rise among teens
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Findings from the 2019 Monitoring the Future (MTF) survey demonstrate the appeal of vaping to teens, as seen in the increased prevalence of marijuana use as well as nicotine vaping.
α2δ-1–NMDA Receptor Interactions Are Responsible for Increases in Pain Sensitivity Caused by Opioids
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In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment. Blocking the α2δ-1–NMDA...
National Institute on Drug Abuse to hold teleconference discussing key findings of 2019 Monitoring the Future Survey on teen drug use
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The National Institute on Drug Abuse will hold a teleconference discussing key findings of 2019 Monitoring the Future Survey on teen drug use.
Measuring the complex path to a prescription opioid use disorder
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NIDA scientists examine an accepted model of the causes of depression to determine its usefulness as a foundation to predict the probability of prescription opioid use disorder.
New discovery on the brain’s reward pathway
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Scientists at NIDA’s Intramural Research Program (IRP) have identified a population of neurons engaged in the compulsive nature of food seeking, which, like substance use, engage the brain’s reward circuit...
Nerve-Cell Growth During Abstinence From Methamphetamine May Promote Reinstatement of Drug Use in Rats
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Neurogenesis that occurs during abstinence from methamphetamine in a brain region related to memory and learning may promote relapse-like behavior.
Event registration opens for 10th anniversary of National Drug and Alcohol Facts Week®
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The National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) announced that event registration begins today for the 10th annual National Drug and...
NIH-funded study finds teens prefer mint and mango vaping flavors
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A new analysis suggests that teens prefer mint and mango as their vaping flavors of choice for e-cigarettes
Healing the altered brains of smokers
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A study from NIDA’s Intramural Research Program illuminates the roles of the brain’s striatum and habenula in nicotine withdrawal and reward, suggesting that current medications for smoking cessation are not...
Mindful Awareness in Body-Oriented Therapy Proves Useful in Women Treated for Substance Use Disorder
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Mindful Awareness in Body-Oriented Therapy (MABT) improved emotion regulation, reduced craving, and promoted abstinence in women with a history of trauma and emotional problems receiving outpatient treatment for substance use...
Who is most likely to become addicted to nicotine?
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NIDA scientists discover that connectivity between insular regions of the brain before using nicotine can predict severity of addiction.
Racial and Socioeconomic Disparities in Tobacco Smoke Exposure Persist Among U.S. Children
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The number of children (ages 3 to 11 years) in the United States who are exposed to tobacco smoke decreased steadily from 1999 to 2014. However, childhood tobacco smoke exposure...
Marijuana and America’s Health: Questions and Issues for Policy Makers
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Go to the Senate Caucus on International Narcotics Control site Chairman Cornyn, Co-Chairwoman Feinstein and members of the Caucus on International Narcotics Control, we appreciate the opportunity to share the...
Nicotine addiction linked to diabetes through a DNA-regulating gene in animal models
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Researchers have discovered a mechanism in rats that links cigarette smoking and the risk of developing type 2 diabetes.
Machine Learning Applied to Brain Imaging Data Predicts Response to Cocaine Use Disorder Treatment
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This study demonstrated that functional connectivity among a large number of brain regions predicts patients’ chances of achieving abstinence in treatment for cocaine use disorder.
NIDA-NIAAA 2019 Mini-Convention: Frontiers in Addiction Research
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The National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), both part of the National Institutes of Health, will host a one-day mini-convention...
Measuring sleep challenges in opioid use disorder patients
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A new study at NIDA’s Intramural Research Center measured sleep patterns in opioid use disorder patients and found that clinic appointment hours make a difference in sleep quality. They also...
Teen e-cigarette use doubles since 2017
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Data from the 2019 Monitoring the Future Survey of eighth, 10th and 12th graders show alarmingly high rates of e-cigarette use compared to just a year ago, with rates doubling...
Marijuana use at historic highs among college-age adults
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Newly released Monitoring the Future (MTF) survey data on drug use in college-age adults ages 19-22 shows an increase in marijuana use in the past five years, including vaping with...
CDC and FDA Issue Updates on Vaping-Related Health Issues
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The CDC and FDA have posted important information for consumers related to recent deaths and illnesses that could be linked to vaping.
NASEM releases National Agenda on Children’s Behavioral Health
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The National Academies of Sciences, Engineering and Medicine has released a national scientific agenda on Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth, recommending a comprehensive approach...
Unraveling the mystery of the glutamate-dopamine connection
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Investigators identify a subpopulation of calbindin neurons with the capability to co-release glutamate and dopamine in the nucleus accumbens shell.
U.S. Surgeon General Warning on Marijuana Use in Adolescence and During Pregnancy
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The U.S. Surgeon General has issued a warning about the potential health risks of marijuana use in adolescence and during pregnancy.
Worms lead scientists to a new anti-opioid system
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A team of NIH-funded scientists used worms to discover a surprising biological system that counteracts the effects of opioids, offering a potential new target for improving the safety of opioid...
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This study showed that rats will forgo heroin and methamphetamine in favor of spending time with another rat. It also highlights the importance of incorporating voluntary choice between drugs and...
New findings could lead to reduced replication of the HIV virus
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In this study, NIDA-funded scientists found that the HIV RNA genome has two previously unknown types of RNA marks.
Teens who misuse medicines get them from multiple sources
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Two NIDA-funded studies have found that adolescents using multiple sources for prescription medications are at high risk for other substance use.