E-Cigarettes Promote Smoking Progression in Youth and Depress Quitting Among Adults
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E-cigarettes are not an effective tool to reduce combustible-cigarette smoking, two NIDA-supported studies indicate.
Research Highlights
Pregnant women in Appalachia face barriers to opioid treatment
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A NIDA-funded study has discovered that pregnant women in Appalachia face barriers to receiving medication-assisted treatment for opioid use disorders, from both insurers and providers.
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This research: Sheds light on a key mechanism of adolescent brain development. Shows how amphetamine disrupts this mechanism. Links this disruption to animal behaviors that resemble human susceptibility to addiction...
NIH Partners with the Dental Community to Help Curb the Opioid Crisis
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Reducing healthcare’s reliance on potentially addictive opioid pain relievers has been one of the pillars of federal efforts to reverse the opioid crisis.
As Opioid Use Disorders Increased, Prescriptions for Treatment Did Not Keep Pace
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Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to...
FDA Approves First Drug Derived from Marijuana
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This week, the Food and Drug Administration (FDA) approved Epidiolex (cannabidiol, or CBD), a medication extracted from marijuana, for the treatment of two severe pediatric seizure disorders.
A revealing look at the brain on heroin
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A NIDA-funded study reveals major changes in the brains of heroin users.
Scientists discover path to better pain medicines
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In this this NIDA-funded research, scientists used a novel approach to compare the cell signaling initiated by kappa opioids that produce dysphoria from those that do not.
Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT
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This clinical trial: Found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they...
In Animals, Opioid Combination Shows Promise for Safer Pain Relief
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This study found that: In rats, co-administration with nalfurafine reduced the dose of oxycodone required to lower pain responses in models of human chronic pain. The combination treatment generated less...
A Gene Links Impulsivity and Drug Use Vulnerability
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This research: Identified a gene variant that promotes impulsive behavior and enhanced responses to heroin in rats. Linked the corresponding human gene variant to increased risk for impulsivity and drug...
Novel Compound Alleviates Hard-to-Treat Pain in Mice
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A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.
An Ambitious Research Plan to Help Solve the Opioid Crisis
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In spring 2018, Congress added an additional $500 million to the NIH budget to invest in science to find solutions to the opioid crisis. The funding that NIDA is receiving...
Too Hot And Too Cold: Dysregulation of key brain networks in people with addiction
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Study suggests that brain activity is not simply too high or low in people who are addicted to drugs, but behaves differently to drug and non-drug stimuli.
Cigarette Smoking Increases the Likelihood of Drug Use Relapse
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This research: Found that cigarette smoking increased the likelihood of relapse among people in recovery from substance use disorder (SUD). Suggests that helping patients quit and remain abstinent from smoking...
Breathing under the influence of … fentanyl
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An animal study at NIDA's intramural research labs suggests fentanyl-induced respiratory depression affects the temperature of the brain, triggering brain hypoxia and hyperglycemia.
NIDA-Supported Science Leads to First FDA-Approved Medication for Opioid Withdrawal
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This week, the Food and Drug Administration (FDA) approved lofexidine, the first medication targeted specifically to treat the physical symptoms associated with opioid withdrawal.
What science says about Tobacco + Marijuana + Pregnancy
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A NIDA-funded study suggests that pregnant women who smoke both marijuana and cigarettes have a higher likelihood of smaller babies and increased maternal stress and aggression.
Million-Participant NIH Study Could Yield Important Insights into Addiction and Pain
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New data-gathering and analytic capabilities are enabling the kinds of massive, long-term studies needed to investigate genetic, environmental, and lifestyle factors that contribute to disease.
Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3
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Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first-ever medication to treat methamphetamine addiction. She and colleagues at the Universities of...
The True, Deadly Scope of America’s Fentanyl Problem
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Today, a new analysis in JAMA by epidemiologists at NIDA and the Substance Abuse and Mental Health Services Administration reveals the scope of the crisis, and the rapidity with which...
Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients
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In this research: Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics. Neither pain severity nor...
Overdose drug shows promise as stroke treatment
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Preclinical research lays the groundwork for developing the first drug to promote recovery from ischemic stroke, a leading cause of adult disability.
Communities That Care program shows success in reducing substance use and behavioral issues in adolescents
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The CTC is a prevention planning and implementation system that trains community coalition is to assess their community’s needs, then select and use evidence-based programs and policies to reduce risk...
Listening to Patients’ Voices in Developing New Opioid Addiction Treatments
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One of the pillars of the current federal initiatives to end the opioid crisis is the development of new medications to treat opioid addiction. The FDA Patient-Focused Drug Development Initiative...
Study highlights how opioid receptors organize to block pain
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A NIDA-funded study explored how opioids such as morphine act within pain circuits in the brain and spinal cord, while attaching to receptors on the surface of nerve cells (neurons).
What Does It Mean When We Call Addiction a Brain Disorder?
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Informed Americans no longer view addiction as a moral failing, and more and more policymakers are recognizing that punishment is an ineffective and inappropriate tool for addressing a person’s drug...
Gut-brain axis offers clues to treatments for addictive disorders
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Scientists have investigated how the stomach-derived hormone ghrelin affects alcohol-seeking behaviors, discovering for the first time in humans that administration of ghrelin intravenously significantly increased alcohol intake in heavy drinking...
Stimulating news about brain glutamate
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NIDA-funded scientists conducted the first study showing that the signaling transmitter glutamate increases in the brain after stimulant use in humans, which has a greater effect in females.
Why Marijuana Displeases
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Through research on mice, a mechanism for how THC, the active ingredient in marijuana can produce rewarding, neutral or negative experiences was demonstrated.