The NIDA Avant-Garde Award Program for HIV/AIDS Research is now open to international scientists. This award is designed to support individual scientists of exceptional creativity who propose cutting-edge—and possibly transformative—approaches to major challenges in biomedical and behavioral research on HIV/AIDS that are relevant to drug abuse. The award is intended to support high-impact research that will open new areas of HIV/AIDS research and/or lead to new avenues for treatment and prevention of HIV/AIDS among drug abusers. Proposed research should reflect ideas and approaches that are substantially different from those already being studied by the investigator or others. Avant-Garde awardees are required to commit at least 35% of their research effort to activities supported by the Avant-Garde Award. Pre-application is required, as explained in the announcement PAR-12-164. For more information about the Avant-Garde Award, see the full Request for Applications, RFA-DA-13-002 FY13 NIDA Avant-Garde Award Program for HIV/AIDS Research (DP1).