The alarming state of health disparities among vulnerable populations in the United States is a serious public health concern and has garnered wide-spread attention from the United States government leadership (e.g., HHS, Congress), the NIH, and the public, especially with the current COVID-19 pandemic.
Addressing health disparities will require a multi-level approach so it is important to know what has been done, what is currently being done, and what research still needs to be done in this area. The purpose of this webpage is to house active funding opportunity announcements as well as list other NIDA initiatives focused on reducing health disparities and improving the health of vulnerable populations. This list of FOAs will be updated periodically so that we are displaying current FOAs, but for the most current list of FOAs, please see the NIH Guide. Below we have provided a brief definition of a health disparity and populations affected by health disparities.
What is a health disparity?
A health disparity is defined as “a particular type of health difference that is closely linked with social, economic, and/or environmental disadvantage. Health disparities adversely affect groups of people who have systematically experienced greater obstacles to health based on their racial or ethnic group; religion; socioeconomic status; gender; age; mental health; cognitive, sensory, or physical disability; sexual orientation or gender identity; geographic location; or other characteristics historically linked to discrimination or exclusion” (U.S. Department of Health and Human Services and Healthy People 2020).
What populations are adversely affected by health disparities?
NIH-designated U.S. health disparity populations include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. See NOT-OD-15-089.
- U.S. Department of Health and Human Services. The Secretary’s Advisory Committee on National Health Promotion and Disease Prevention Objectives for 2020. Phase I report: Recommendations for the framework and format of Healthy People 2020 [Internet]. Section IV: Advisory Committee findings and recommendations [cited 2010 January 6]. https://www.healthypeople.gov/2020/About-Healthy-People/History-Development-Healthy-People-2020
NIDA Health Disparities Funding Opportunity Announcements
Limited Interaction Targeted Epidemiology (LITE-2): To Advance HIV Prevention (UG3/UH3 Clinical Trial Optional)
This funding opportunity announcement solicits applications that use innovative technology to conduct epidemiologic studies of large cohorts of U.S. populations at high risk of HIV acquisition: men who have sex with men (MSM), people who inject drugs (PWID), and transgender women and men, focusing especially on the minority and age groups at highest risk of HIV transmissions.
FOA: RFA-AI-21-018 Expiration Date: August 05, 2021
Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Use and Addiction Scientists (R25 Clinical Trials Not Allowed)
The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research
FOA: PAR-20-236 Next Application Due Date: August 10, 2021
Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 Clinical Trial Optional)
This initiative will support (1) observational research to understand the role of structural racism and discrimination (SRD) in causing and sustaining health disparities, and (2) intervention research that addresses SRD in order to improve minority health or reduce health disparities.
FOA: RFA-MD-21-004 Expiration Date: August 25, 2021
Support for Research Excellence – First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)
SuRE is a research capacity building program designed to develop and sustain research excellence in U.S. higher education institutions that receive limited NIH research support and serve students from groups underrepresented in biomedical research with an emphasis on providing students with research opportunities and enriching the research environment at the applicant institutions.
FOA: PAR-21-173 Next Application Due Date: September 28, 2021
Innovative Models for Delivering PrEP and STI Services to Stop HIV in the United States (R61/R33 Clinical Trial Optional)
The purpose of this funding opportunity is to encourage and support the development of effective strategies for expanding the provision of HIV pre-exposure prophylaxis (PrEP) for people at increased risk but currently lacking these services by leveraging existing sexually transmitted infection (STI) programs.
FOA: RFA-AI-20-069 Expiration Date: October 13, 2021
Mechanistic Studies on the Impact of Social Inequality on the Substance Use Trajectory (R21 - Basic Experimental Studies with Humans Required)
This funding opportunity invites mechanistic studies on the impact of social inequality on the brain and on the substance use trajectory. Applications investigating relevant mechanisms at the behavioral, cognitive, neurocircuitry, cellular, genetics, and epigenetics levels are encouraged.
FOA: RFA-DA-22-030 Application Due Date: October 14, 2021
Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 - Clinical Trial Optional)
This Funding Opportunity Announcement (FOA) encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials. Relevant trials may test a wide range of approaches, including interventions, practices, and policies designed to optimize access to, and the quality, effectiveness, affordability and utilization of drug, tobacco, or alcohol use disorder treatments and related services, as well as services for comorbid medical and mental disorder conditions.
FOA: PA-21-180 Expiration Date: October 16, 2021
Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed)
The purpose of this FOA is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
FOA: PAR-21-213 Expiration Date: November 08, 2021
Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations (R01 Clinical Trial Optional)
This funding opportunity announcement invites applications that seek to understand strategies to reduce disparities in the uptake of evidence-based screening (e.g. screening recommendations proven to be effective based on rigorous systematic review of scientific evidence by authoritative committees) across the adult lifespan. Research supported by this initiative should enhance the screening process related to use: (1) in diverse populations, (2) in diverse clinical and community settings, and/or (3) with traditional, non-traditional and/or allied health care providers.
FOA: PA-18-932 Expiration Date: January 8, 2022
Notice of NIDA's Participation in NOT- MD-21-008 "Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities"
NIDA seeks to support research in addressing SARS-CoV-2 vaccine implementation among populations with current substance use and substance use disorders, particularly those from NIH-designated U.S. health disparity populations. Additionally, NIDA is interested in research on understanding and increasing engagement in SUD vaccine clinical trials among health disparity populations.
Notice: NOT-DA-22-015 Expiration Date: January 8, 2022
Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
The SuRE program seeks to develop and sustain research excellence of faculty investigators and provide students with research opportunities while catalyzing institutional research and enriching the research environment.
FOA: PAR-21-169 Next Application Due Date: May 26, 2022
Getting To Zero: Understanding HIV Viral Suppression and Transmission in the United States (R01 Clinical Trial Optional
The purpose of this funding opportunity announcement is to support grants to improve understanding of viral suppression and HIV transmission in the U.S. using population-level epidemiology, novel tools from data science approaches and m/eHealth, and implementation science research. Data generated through this research will be used to inform and evaluate context-specific HIV control strategies towards the goal of ending the HIV epidemic in the U.S.
FOA: PAR-20-036 Expiration Date: September 8, 2022
Health Services Research on Minority Health and Health Disparities (R01- Clinical Trial Optional)
The purpose of this funding opportunity announcement is to encourage innovative health services research that can directly and demonstrably contribute to the improvement of minority health and/or the reduction of health disparities at the health care system-level as well as within clinical settings.
FOA: PAR-20-310 Expiration Date: March 28, 2023
Notice of Special Interest (NOSI): Simulation Modeling and Systems Science to Address Health Disparities
The purpose of this Notice of Special Interest is to support investigative and collaborative research focused on developing and evaluating simulation modeling and systems science to understand and address minority health and health disparities.
Notice: NOT-MD-20-025 Expiration Date: May 08, 2023
New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial Required):
New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Required)
The purpose of this funding opportunity announcement is to support the testing of enhanced models of care that optimally integrate HIV, addiction, and primary care services. NIDA is interested in research that addresses gaps related to the delivery of comprehensive, integrated health services to include the full continuum of HIV/AIDS services, addiction prevention and treatment services, and primary care services, with a goal of improving the coordination of care, and improving health outcomes related to HIV and SUD in the US for populations who are at high risk.
FOA: PAR-20-273 Expiration Date: August 12, 2023
FOA: PAR-20-274 Expiration Date: August 12, 2023
Long-Term Effects of Disasters on Health Care Systems Serving Health Disparity Populations (R01- Clinical Trial Optional
The overarching goal of this funding opportunity announcement is to invite robust investigative and collaborative research focused on understanding the long-term effects of disasters on health disparity populations and the health care systems that serve them, including the influence of risk factors or vulnerabilities of both the systems and the communities preceding the event(s).
FOA: PA-20-172 Expiration Date: September 8, 2023
Research to Improve Native American Health (R21 Clinical Trials Optional)
The purpose of this funding opportunity announcement is to support developmental/exploratory studies in preparation for health promotion, disease prevention, treatment, or treatment services research to improve health in Native American (NA) populations. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this announcement, culturally informed exploratory/developmental research is sought that builds upon community knowledge, resources, and resilience to provide foundational knowledge for future science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment.
FOA: PAR-20-214 Expiration Date: September 8, 2023
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
The purpose of this funding opportunity announcement (FOA) is to support research on interventions to improve health in Native American (NA) populations. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment.
FOA: PAR-20-238 Expiration Date: September 8, 2023
Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)
The purpose of this funding opportunity announcement is to support creative educational activities with a primary focus on research experiences for high school students, undergraduate students, and/or science teachers during the summer academic break.
FOA: PAR-21-168 Expiration Date: May 08, 2024
Notice of Special Interest: Public Policy Effects on Alcohol-, Cannabis-, Tobacco-, and Other Drug-Related Behaviors and Outcomes
This announcement encourages applications to conduct research on the effects of public policies on health-related behaviors and outcomes associated with alcohol, cannabis, tobacco, prescription drugs, and other substances. The purpose of the Notice is to advance understanding of how public policy may serve as a tool for improving public health and welfare through its effects on behaviors and outcomes pertaining to alcohol and other drugs.
Notice: NOT-AA-21-028 Expiration Date: September 08, 2024