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Suboxone® (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules

Suboxone Buprenorphine/Naloxone Taper

This study was undertaken to compare, in an outpatient setting, the relative advantage of two Suboxone® (Bup/Nx) tapering schedules (one rapid and one gradual) following four weeks of Suboxone® stabilization, as reflected by the proportion of participants providing opiate free urines at the end of the taper regimen. In total, 516 participants were randomized to one of two taper schedules, either 7 days or 28 days. The reason for conducting this study was not to advocate for short-term treatment, but to determine the relative ease of using a more rapid vs. a gradual taper should someone need to discontinue Bup/Nx.

CTN Protocol ID: 
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Primary Outcomes Article: 

Ling, W., et al. (2009).  Buprenorphine tapering schedule and illicit opioid use.  Addiction 104: 256-265.

Principal Investigator(s)
Walter Ling, M.D.
Integrated Substance Abuse Programs
University of California, Los Angeles
11075 Santa Monica Boulevard
Suite 200
Los Angeles, CA 90025

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