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Prescription Opioid Addiction Treatment Study (POATS)

Bottle knocked over with pills on the table

This was a randomized outpatient study for treatment-seeking participants dependent on prescription opioid analgesics. The primary objective was to determine whether the addition of individual drug counseling to the prescription of buprenorphine/naloxone (Bup/Nx) and Standard Medical Management (SMM) improves outcome. Participants were randomized at the beginning of each of two phases to receive BUP/NX paired with either Standard Medical Management (SMM) or Enhanced Medical Management (EMM; defined as SMM plus individual counseling). Six hundred and fifty three participants were randomized into Phase 1, and 360 participants were randomized into Phase 2.

CTN Protocol ID: 
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ClinicalTrials.gov ID: 
Primary Outcomes Article: 

Weiss, et al. (2011).  Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence.  Archives of General Psychiatry.  68(12):1238-1246.

Principal Investigator(s)
Roger D. Weiss, M.D.
Division of Alcohol and Drug Abuse
McLean Hospital
115 Mill Street
Belmont, MA 2478

Walter Ling, M.D.
Integrated Substance Abuse Programs
University of California, Los Angeles
11075 Santa Monica Boulevard
Suite 200
Los Angeles, CA 90025

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