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Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Inpatient Opiate Detoxification

Bup/Nx and Clonidine: A Medication Comparison Study cover

For decades, clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, one of the most effective means to achieving that goal, has been unavailable outside the very restrictive confines of narcotic treatment programs. Bup/Nx shows promise as an effective aid for opiate detoxification; however, little data have been generated for the shorter-term use of Bup/Nx for this indication. Because the diversity of clinics in the CTN provides an unparalleled opportunity to conduct such a clinical endeavor, the utility of Bup/Nx in short term (13 day) detoxification versus clonidine in an inpatient setting was tested in the CTN.

CTN Protocol ID: 
ClinicalTrials.gov ID: 
Primary Outcomes Article: 

Ling, W., et al. (2005).  A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings for the National Institute on Drug Abuse Clinical Trials Network.  Addiction 100:1090-1110.

Principal Investigator(s)
Walter Ling, M.D.
Integrated Substance Abuse Programs
University of California, Los Angeles
11075 Santa Monica Boulevard
Suite 200
Los Angeles, CA 90025

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