Other Drugs

Molecular Genetics

• The collaborative cross: a recombinant inbred mouse population for the systems genetic era. Threadgill DW, Miller DR, Churchill GA, de Villena FP. ILAR J. 2011 Feb 8;52(1):24-31. Review.
• Genetic analysis of complex traits in the emerging Collaborative Cross. Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA. Genome Res. 2011 Aug;21(8):1213-22.
• Genetic analysis in the Collaborative Cross breeding population. Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Shaw GS, Shinpock S, Manly KF, Miller DR, Donohue KD, Culiat CT, Churchill GA, Lariviere WR, Palmer AA, O'Hara BF, Voy BH, Chesler EJ. Genome Res. 2011 Aug;21(8):1223-38.
• S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Ho GP, Selvakumar B, Mukai J, Hester LD, Wang Y, Gogos JA, Snyder SH. Neuron. 2011 Jul 14;71(1):131-41.
• S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Ho GP, Selvakumar B, Mukai J, Hester LD, Wang Y, Gogos JA, Snyder SH. Neuron. 2011 Jul 14;71(1):131-41.
• Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Behav Brain Res. 2011 Nov 20;225(1):348-57.
• Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ. J Neurosci. 2011 Jul 20;31(29):10506-15.
• Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX, Pasternak GW. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19778-83.
• Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C. Neuron. 2011 Aug 11;71(3):498-511.
• Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Larson EB, Graham DL, Arzaga RR, Buzin N, Webb J, Green TA, Bass CE, Neve RL, Terwilliger EF, Nestler EJ, Self DW. J Neurosci. 2011 Nov 9;31(45):16447-57.
• ΔFosB Enhances the Rewarding Effects of Cocaine While Reducing the Pro-Depressive Effects of the Kappa-Opioid Receptor Agonist U50488. Muschamp JW, Nemeth CL, Robison AJ, Nestler EJ, Carlezon WA Jr. Biol Psychiatry. 2012 Jan 1;71(1):44-50. Epub 2011 Sep 29.
• A role for repressive histone methylation in cocaine-induced vulnerability to stress. Covington HE 3rd, Maze I, Sun H, Bomze HM, DeMaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ. Neuron. 2011 Aug 25;71(4):656-70.
• FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB. Ohnishi YN, Ohnishi YH, Hokama M, Nomaru H, Yamazaki K, Tominaga Y, Sakumi K, Nestler EJ, Nakabeppu Y. Biol Psychiatry. 2011 Sep 1;70(5):487-95.
• A silent synapse-based mechanism for cocaine-induced locomotor sensitization. Brown TE, Lee BR, Mu P, Ferguson D, Dietz D, Ohnishi YN, Lin Y, Suska A, Ishikawa M, Huang YH, Shen H, Kalivas PW, Sorg BA, Zukin RS, Nestler EJ, Dong Y, Schlüter OM. J Neurosci. 2011 Jun 1;31(22):8163-74.
• Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. J Neurosci. 2011 May 25;31(21):7927-37.
• Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3035-40.
• Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Cao JL, Vialou VF, Lobo MK, Robison AJ, Neve RL, Cooper DC, Nestler EJ, Han MH. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17011-6.
• Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, Ghose S, Vernov M, Stavarache M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Sci Transl Med. 2010 Oct 20;2(54):54ra76. Erratum in: Sci Transl Med. 2010 Oct 27;2(55):55er3. Arango-Llievano, Margarita [corrected to Arango-Lievano, Margarita]; Stavarche, Mihaela [corrected to Stavarache, Mihaela].
• IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ. J Neurosci. 2011 Jan 5;31(1):314-21.
• Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N. Neuron. 2011 Feb 10;69(3):437-44.
• Rheb1 is required for mTORC1 and myelination in postnatal brain development. Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B. Dev Cell. 2011 Jan 18;20(1):97-108.
• Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. J Neurosci. 2011 May 25;31(21):7927-37.
• Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Wei LN, Loh HH. Annu Rev Pharmacol Toxicol. 2011 Feb 10;51:75-97. Review.
• Endocytosis promotes rapid dopaminergic signaling. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Neuron. 2011 Jul 28;71(2):278-90.
• SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M. Nat Cell Biol. 2011 Jun;13(6):715-21.
• Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone. Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT. J Neurosci. 2011 Mar 23;31(12):4434-43.
• Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Puthenveedu MA, Lauffer B,  Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Cell. 2010 Nov 24;143(5):761-73.
• Galanin negatively modulates opiate withdrawal via galanin receptor 1. Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V. Psychopharmacology (Berl). 2011 Oct 4. [Epub ahead of print]
• Reduced locomotor responses to cocaine in ghrelin-deficient mice. Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL. Neuroscience. 2011 Sep 29;192:500-6.
• FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. Guez-Barber D, Fanous S, Golden SA, Schrama R, Koya E, Stern AL, Bossert JM, Harvey BK, Picciotto MR, Hope BT. J Neurosci. 2011 Mar 16;31(11):4251-9.
• Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance. Johnson AW, Han S, Blouin AM, Saini J, Worley PF, During MJ, Holland PC, Baraban JM, Reti IM. Learn Mem. 2010 Nov 22;17(12):620-6.
• Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons. Wen JA, Barth AL. J Neurosci. 2011 Mar 23;31(12):4456-65.
• Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14300-5.
• Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV. Kelschenbach JL, Saini M, Hadas E, Gu CJ, Chao W, Bentsman G, Hong JP, Hanke T, Sharer LR, Potash MJ, Volsky DJ. J Neuroimmune Pharmacol. 2011 Oct 11. [Epub ahead of print]
• Inducible genetic lineage tracing of cortical hem derived cajal-retzius cells reveals novel properties. Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y, Pleasure SJ, Zhao C. PLoS One. 2011;6(12):e28653.
• An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis. Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C.Genesis. 2011 Dec;49(12):919-26. doi: 10.1002/dvg.20765. Epub 2011 Oct 13.
• Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ. J Neurosci. 2011 Feb 2;31(5):1676-87.
• CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL. Neuron. 2011 Jan 13;69(1):61-76.
• Microfluidic chamber arrays for whole-organism behavior-based chemical screening. Chung K, Zhan M, Srinivasan J, Sternberg PW, Gong E, Schroeder FC, Lu H. Lab Chip. 2011 Nov 7;11(21):3689-97.
• Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters. Schmidt HD, Sangrey GR, Darnell SB, Schassburger RL, Cha JH, Pierce RC, Sadri-Vakili G. J Neurochem. 2011 Nov 2. doi: 10.1111/j.1471-4159.2011.07571.
• Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use. Berger AC, Whistler JL. EMBO Mol Med. 2011 Jul;3(7):385-97.
• Developmental mechanisms for the generation of telencephalic interneurons. Corbin JG, Butt SJ. Dev Neurobiol. 2011 Aug;71(8):710-32. doi: 10.1002/dneu.20890. Review.
• Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system. Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG. J Neurosci. 2011 Apr 6;31(14):5313-24.
• Highwire regulates guidance of sister axons in the Drosophila mushroom body. Shin JE, Diantonio A. J Neurosci. 2011 Nov 30;31(48):17689-700.
• Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Tian X, Li J, Valakh V, DiAntonio A, Wu C. Nat Neurosci. 2011 Aug 28;14(10):1267-75.
• Csnk1e Is a Genetic Regulator of Sensitivity to Psychostimulants and Opioids. Bryant CD, Parker CC, Zhou L, Olker C, Chandrasekaran RY, Wager TT, Bolivar VJ, Loudon AS, Vitaterna MH, Turek FW, Palmer AA. Neuropsychopharmacology. 2011 Nov 16. doi: 10.1038/npp.2011.287
• Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line. Parker CC, Cheng R, Sokoloff G, Palmer AA. Genes Brain Behav. 2011 Oct 27. doi: 10.1111/j.1601-183X.2011.00747.x
• Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA. J Neurosci. 2011 Aug 31;31(35):12554-65.
• microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR. RNA. 2011 Aug;17(8):1529-43.
• Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. Mains RE, Kiraly DD, Eipper-Mains JE, Ma XM, Eipper BA. BMC Neurosci. 2011 Feb 17;12:20.
• Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers. Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL. Biol Psychiatry. 2011 Feb 1;69(3):245-52.
• Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. Stoker AK, Olivier B, Markou A. Psychopharmacology (Berl). 2011 Dec 3 [Epub ahead of print]
• MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. PLoS Biol. 2011 Dec;9(12):e1001214.
• Modeling the Diagnostic Criteria for Alcohol Dependence with Genetic Animal Models. Crabbe JC, Kendler KS, Hitzemann RJ.  Curr Top Behav Neurosci. 2011 Sep 11. [Epub ahead of print]
• HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, Mercier S, Jones K, Nasr N, Rustagi A, Cumming H, Donaghy H, Mak J, Gale M Jr, Churchill M, Hertzog P, Cunningham AL. Blood. 2011 Jul 14;118(2):298-308.
• Clonal production and organization of inhibitory interneurons in the neocortex. Brown KN, Chen S, Han Z, Lu CH, Tan X, Zhang XJ, Ding L, Lopez-Cruz A, Saur D, Anderson SA, Huang K, Shi SH. Science. 2011 Oct 28;334(6055):480-6.
• Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification. Fujimoto E, Stevenson TJ, Chien CB, Bonkowsky JL. Dev Biol. 2011 Apr 15;352(2):393-404.
• DNA methylation: a transcriptional mechanism co-opted by the developed mammalian brain? Mikaelsson MA, Miller CA. Epigenetics. 2011 May;6(5):548-51.
• SDF1-induced antagonism of axonal repulsion requires multiple G-protein coupled signaling components that work in parallel.Twery EN, Raper JA. PLoS One. 2011 Apr 27;6(4):e18896.
• Adolescent opioid exposure in female rats: transgenerational effects on morphine analgesia and anxiety-like behavior in adult offspring. Byrnes JJ, Babb JA, Scanlan VF, Byrnes EM. Behav Brain Res. 2011 Mar 17;218(1):200-5.
• Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. Hale CF, Dietz KC, Varela JA, Wood CB, Zirlin BC, Leverich LS, Greene RW, Cowan CW. J Neurosci. 2011 Aug 31;31(35):12426-36.
• Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2. Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J. J Virol. 2011 Sep;85(17):9078-89.
• The emerging role for rat models in gene discovery. Dwinell MR, Lazar J, Geurts AM.Mamm Genome. 2011 Aug;22(7-8):466-75. Review.
• Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse. Miczek KA, Nikulina EM, Takahashi A, Covington HE 3rd, Yap JJ, Boyson CO, Shimamoto A, de Almeida RM. Behav Genet. 2011 Nov;41(6):787-802.
• CBP in the Nucleus Accumbens Regulates Cocaine-Induced Histone Acetylation and Is Critical for Cocaine-Associated Behaviors. Malvaez M, Mhillaj E, Matheos DP, Palmery M, Wood MA.J Neurosci. 2011 Nov 23;31(47):16941-8.
• Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. Abul-Husn NS, Annangudi SP, Ma'ayan A, Ramos-Ortolaza DL, Stockton SD Jr, Gomes I, Sweedler JV, Devi LA. PLoS One. 2011;6(10):e25535.
• Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. Gantz SC, Ford CP, Neve KA, Williams JT. J Neurosci. 2011 Aug 31;31(35):12629-37.
• Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C. Neuron. 2011 Aug 11;71(3):498-511.
• Integrins modulate relapse to cocaine-seeking. Wiggins A, Smith RJ, Shen HW, Kalivas PW.J Neurosci. 2011 Nov 9;31(45):16177-84.
• Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Kotsikorou E, Madrigal KE, Hurst DP, Sharir H, Lynch DL, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak L, Abood ME, Reggio PH.  Biochemistry. 2011 Jun 28;50(25):5633-47.
• Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC.  Science. 2010 Nov 19;330(6007):1091-5.
• Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9.
• Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Liu X, Li F, Stubblefield EA, Blanchard B, Richards TL, Larson GA, He Y, Huang Q, Tan AC, Zhang D, Benke TA, Sladek JR, Zahniser NR, Li CY. Cell Res. 2011 Nov 22. doi: 10.1038/cr.2011.181. [Epub ahead of print]
• Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. Abul-Husn NS, Annangudi SP, Ma'ayan A, Ramos-Ortolaza DL, Stockton SD Jr, Gomes I, Sweedler JV, Devi LA. PLoS One. 2011;6(10):e25535.
• Stretched Tissue Mounting for MALDI Mass Spectrometry Imaging. Tucker KR, Lanni EJ, Serebryannyy LA, Rubakhin SS, Sweedler JV. Anal Chem. 2011 Dec 1;83(23):9181-5.
• Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex. Fossat P, Turpin FR, Sacchi S, Dulong J, Shi T, Rivet JM, Sweedler JV, Pollegioni L, Millan MJ, Oliet SH, Mothet JP. Cereb Cortex. 2011 Jun 20. [Epub ahead of print]
• Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. Segall SK, Nackley AG, Diatchenko L, Lariviere WR, Lu X, Marron JS, Grabowski-Boase L, Walker JR, Slade G, Gauthier J, Bailey JS, Steffy BM, Maynard TM, Tarantino LM, Wiltshire T. Genes Brain Behav. 2010 Nov;9(8):933-46. doi: 10.1111/j.1601-183X.2010.00633.
• R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Terzi D, Cao Y, Agrimaki I, Martemyanov KA, Zachariou V.   Neuropsychopharmacology. 2011 Nov 16. doi: 10.1038/npp.2011.284.
• R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Terzi D, Cao Y, Agrimaki I, Martemyanov KA, Zachariou V. Neuropsychopharmacology. 2011 Nov 16. doi: 10.1038/npp.2011.284.
• Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. Hale CF, Dietz KC, Varela JA, Wood CB, Zirlin BC, Leverich LS, Greene RW, Cowan CW. J Neurosci. 2011 Aug 31;31(35):12426-36.
• Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2. Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J. J Virol. 2011 Sep;85(17):9078-89.
• A silent synapse-based mechanism for cocaine-induced locomotor sensitization. Brown TE, Lee BR, Mu P, Ferguson D, Dietz D, Ohnishi YN, Lin Y, Suska A, Ishikawa M, Huang YH, Shen H, Kalivas PW, Sorg BA, Zukin RS, Nestler EJ, Dong Y, Schlüter OM. J Neurosci. 2011 Jun 1;31(22):8163-74.
• Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons. Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli A, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ. Neuron. 2011 Dec 22;72(6):977-90.
• Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. Palmer AA, de Wit H. Hum Genet. 2011 Dec 15. [Epub ahead of print]

Human Genetics

• Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol. Zhou Z, Yuan Q, Mash DC, Goldman D. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6626-31.
• MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. PLoS Biol. 2011 Dec;9(12):e1001214.
• Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Edwards AC, Aliev F, Bierut LJ, Bucholz KK, Edenberg H, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Schuckit MA, Porjesz B, Dick DM.Psychiatr Genet. 2012 Feb;22(1):31-41.
• ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Bierut LJ, Goate AM, Breslau N, Johnson EO, Bertelsen S, Fox L, Agrawal A, Bucholz KK, Grucza R, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Porjesz B, Saccone NL, Schuckit M, Tischfield J, Wang JC, Foroud T, Rice JP, Edenberg HJ. Mol Psychiatry. 2011 Oct 4. doi: 10.1038/mp.2011.124.
• CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek MJ. Addict Biol. 2011 Jul 25. doi: 10.1111/j.1369-1600.2011.00349.x.
• The AVPR1A gene and substance use disorders: association, replication, and functional evidence. Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Heidbreder C, Muglia P, Murrelle EL, Dick DM, Aliev F, Agrawal A, Edenberg HJ, Kramer J, Nurnberger J, Tischfield JA, Devlin B, Ferrell RE, Kirillova GP, Tarter RE, Kendler KS, Vanyukov MM. Biol Psychiatry. 2011 Sep 15;70(6):519-27.
• Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis. Clarke TK, Bloch PJ, Ambrose-Lanci LM, Ferraro TN, Berrettini WH, Kampman KM, Dackis CA, Pettinati HM, O'Brien CP, Oslin DW, Lohoff FW.  Addict Biol. 2011 Jul 25. doi: 10.1111/j.1369-1600.2011.00346.
• Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Stephens SH, Franks A, Berger R, Palionyte M, Fingerlin TE, Wagner B, Logel J, Olincy A, Ross RG, Freedman R, Leonard S. Psychiatr Genet. 2012 Feb;22(1):1-14.
• The human epigenome browser at washington university. Zhou X, Maricque B, Xie M, Li D, Sundaram V, Martin EA, Koebbe BC, Nielsen C, Hirst M, Farnham P, Kuhn RM, Zhu J, Smirnov I, Kent WJ, Haussler D, Madden PA, Costello JF, Wang T. Nat Methods. 2011 Nov 29;8(12):989-90. doi: 10.1038/nmeth.1772.
• Genomic inflation factors under polygenic inheritance. Yang J, Weedon MN, Purcell S, Lettre G, Estrada K, Willer CJ, Smith AV, Ingelsson E, O'Connell JR, Mangino M, Mägi R, Madden PA, Heath AC, Nyholt DR, Martin NG, Montgomery GW, Frayling TM, Hirschhorn JN, McCarthy MI, Goddard ME, Visscher PM; GIANT Consortium. Eur J Hum Genet. 2011 Jul;19(7):807-12. doi: 10.1038/ejhg.2011.39.
• Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort. Kurbanov F, Abdel-Hamid M, Latanich R, Astemborski J, Mohamed M, Mikhail NM, El-Daly M, El-Kafrawy S, Thomas DL, Thio CL.J Infect Dis. 2011 Nov;204(9):1391-4.
• CXCL9 and CXCL10 chemokines as predictors of liver fibrosis in a cohort of primarily African-American injection drug users with chronic hepatitis C. Zeremski M, Dimova R, Astemborski J, Thomas DL, Talal AH. J Infect Dis. 2011 Sep 15;204(6):832-6.
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