Nicotine

Molecular Genetics

• Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernández-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M. Amino Acids. 2011 Nov 19. [Epub ahead of print]
• Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior. Cohen BN, Mackey ED, Grady SR, McKinney S, Patzlaff NE, Wageman CR, McIntosh JM, Marks MJ, Lester HA, Drenan RM. Neuroscience. 2011 Nov 4. [Epub ahead of print]
• Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. Nature. 2011 Mar 31;471(7340):597-601.
• Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. Dickson PE, Rogers TD, Lester DB, Miller MM, Matta SG, Chesler EJ, Goldowitz D, Blaha CD, Mittleman G. Psychopharmacology (Berl). 2011 Jun;215(4):631-42.
• Nicotine decreases food intake through activation of POMC neurons. Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Science. 2011 Jun 10;332(6035):1330-2.
• Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. Tuesta LM, Fowler CD, Kenny PJ. Biochem Pharmacol. 2011 Oct 15;82(8):984-95.
• Intravenous nicotine self-administration and cue-induced reinstatement in mice: effects of nicotine dose, rate of drug infusion and prior instrumental training. Fowler CD, Kenny PJ. Neuropharmacology. 2011 Sep;61(4):687-98.
• Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. Nature. 2011 Mar 31;471(7340):597-601.
• Tobacco dependence, the insular cortex and the hypocretin connection. Kenny PJ. Pharmacol Biochem Behav. 2011 Feb;97(4):700-7.
• Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits. Tian MK, Bailey CD, De Biasi M, Picciotto MR, Lambe EK. J Neurosci. 2011 Nov 9;31(45):16458-63.
• Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference. Neugebauer NM, Henehan RM, Hales CA, Picciotto MR. Pharmacol Biochem Behav. 2011 Mar;98(1):87-93.
• Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. Stoker AK, Olivier B, Markou A. Psychopharmacology (Berl). 2011 Dec 3  
• Role of α7- and β4-Containing Nicotinic Acetylcholine Receptors in the Affective and Somatic Aspects of Nicotine Withdrawal: Studies in Knockout Mice. Stoker AK, Olivier B, Markou A. Behav Genet. 2011 Oct 19.
• Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. D'Souza MS, Markou A. Neuropharmacology. 2011 Dec;61(8):1399-405
• Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Levine A, Huang Y, Drisaldi B, Griffin EA Jr, Pollak DD, Xu S, Yin D, Schaffran C, Kandel DB, Kandel ER. Sci Transl Med. 2011 Nov 2;3(107):107ra109.
• Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. Nature. 2011 Mar 31;471(7340):597-601.
• Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits. Tian MK, Bailey CD, De Biasi M, Picciotto MR, Lambe EK. J Neurosci. 2011 Nov 9;31(45):16458-63.
• Nicotinic α5 Subunits Drive Developmental Changes in the Activation and Morphology of Prefrontal Cortex Layer VI Neurons. Bailey CD, Alves NC, Nashmi R, De Biasi M, Lambe EK.Biol Psychiatry. 2012 Jan 15;71(2):120-8. Epub 2011 Oct 25.
• Reward, addiction, withdrawal to nicotine. De Biasi M, Dani JA. Annu Rev Neurosci. 2011;34:105-30. Review.
• Promoter Methylation and Tissue-Specific Transcription of the α7 Nicotinic Receptor Gene, CHRNA7. Canastar A, Logel J, Graw S, Finlay-Schultz J, Osborne C, Palionyte M, Drebing C, Plehaty M, Wilson L, Eyeson R, Leonard S. J Mol Neurosci. 2011 Nov 4. [Epub ahead of print]
• Transcriptional Repression of the α7 Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) by Activating Protein-2α (AP-2α). Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. J Biol Chem. 2011 Dec 9;286(49):42123-32.
• In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression. Doyle GA, Wang MJ, Chou AD, Oleynick JU, Arnold SE, Buono RJ, Ferraro TN, Berrettini WH.  PLoS One. 2011;6(8):e23373.

Human Genetics

• Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Biol Psychiatry. 2011 Sep 15;70(6):528-36.
• Reward, addiction, withdrawal to nicotine. De Biasi M, Dani JA. Annu Rev Neurosci. 2011;34:105-30. Review.
• The CHRNA5-A3-B4 gene cluster in nicotine addiction. Berrettini WH, Doyle GA. Mol Psychiatry. 2011 Oct 4. doi: 10.1038/mp.2011.122. [Epub ahead of print]
• Chromosome 20 Shows Linkage With DSM-IV Nicotine Dependence in Finnish Adult Smokers. Keskitalo-Vuokko K, Hällfors J, Broms U, Pergadia ML, Saccone SF, Loukola A, Madden PA, Kaprio J. Nicotine Tob Res. 2012 Feb;14(2):153-60. Epub 2011 Oct 29.
• A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence. Agrawal A, Scherrer JF, Pergadia ML, Lynskey MT, Madden PA, Sartor CE, Grant JD, Duncan AE, Haber JR, Jacob T, Bucholz KK, Xian H. Nicotine Tob Res. 2011 Oct;13(10):972-81.
• A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD, Nelson EC, Henders AK, Schrage AJ, Chou YL, Keskitalo-Vuokko K, Zhu Q, Gordon SD, Vink JM, de Geus EJ, Macgregor S, Liu JZ, Willemsen G, Medland SE, Boomsma DI, Montgomery GW, Rice JP, Goate AM, Heath AC, Kaprio J, Martin NG, Madden PA. Am J Psychiatry. 2011 Aug;168(8):848-52.
• A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes. Maes HH, Neale MC, Chen X, Chen J, Prescott CA, Kendler KS. Behav Genet. 2011 Sep;41(5):680-90.
• Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials. King DP, Paciga S, Pickering E, Benowitz NL, Bierut LJ, Conti DV, Kaprio J, Lerman C, Park PW. Neuropsychopharmacology 2012 Feb;37(3):641-50. Epub 2011 Nov 2.
• A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence. Agrawal A, Scherrer JF, Pergadia ML, Lynskey MT, Madden PA, Sartor CE, Grant JD, Duncan AE, Haber JR, Jacob T, Bucholz KK, Xian H. Nicotine Tob Res. 2011 Oct;13(10):972-81.
• Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Ray R, Ruparel K, Newberg A, Wileyto EP, Loughead JW, Divgi C, Blendy JA, Logan J, Zubieta JK, Lerman C. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9268-73.
• Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. Falcone M, Jepson C, Benowitz N, Bergen AW, Pinto A, Wileyto EP, Baldwin D, Tyndale RF, Lerman C, Ray R. Nicotine Tob Res. 2011 Jun;13(6):498-503.
• Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE.Cancer Epidemiol Biomarkers Prev. 2011 Feb;20(2):234-8.
• Dissection of the Phenotypic and Genotypic Associations With Nicotinic Dependence. Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ. Nicotine Tob Res. 2011 Nov 18. [Epub ahead of print]
• Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM. Hum Mol Genet. 2012 Feb 1;21(3):647-55. Epub 2011 Oct 31.
• The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE. Pharmacogenet Genomics. 2011 Jul;21(7):403-16. doi: 10.1097/FPC.0b013e328346e8c0.
• Common polymorphisms in FMO1 are associated with nicotine dependence. Hinrichs AL, Murphy SE, Wang JC, Saccone S, Saccone N, Steinbach JH, Goate A, Stevens VL, Bierut LJ. Pharmacogenet Genomics. 2011 Jul;21(7):397-402. doi: 10.1097/FPC.0b013e328346886f.
• Genetic vulnerability and susceptibility to substance dependence. Bierut LJ. Neuron. 2011 Feb 24;69(4):618-27. Review.
• Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene. Hartz SM, Lin P, Edenberg HJ, Xuei X, Rochberg N, Saccone S, Berrettini W, Nelson E, Nurnberger J, Bierut LJ, Rice JP; NIMH Genetics Initiative Bipolar Disorder Consortium. Psychiatr Genet. 2011 Apr;21(2):77-84.
• The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior. Breetvelt EJ, Numans ME, Aukes MF, Hoeben W, Strengman E, Luykx JJ, Bakker SC, Kahn RS, Ophoff RA, Boks MP.  Psychiatr Genet. 2011 Oct 15. [Epub ahead of print]
• Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Hum Genet. 2011 Feb;129(2):177-88.
• Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety. Edwards AC, Kendler KS. Nicotine Tob Res. 2011 Aug;13(8):677-85.
• A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. Edwards AC, Maes HH, Pedersen NL, Kendler KS. Psychol Med. 2011 Feb;41(2):395-405.