Revised September 2012
An NIH-funded consortium of The Jackson Laboratory Neuroscience Mutagenesis Center, Northwestern University Neurogenomics Project, and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium, to create, maintain and distribute new mouse models for nervous system function and behavior. (Opens in a new browser window.)
ENU-induced mutagenesis of male and female mice provide mouse models of infertility available for use by the reproductive and developmental biology community. (Opens in a new browser window.)
Harwell ENU Mutagenesis Program
The purpose of the current mutagenesis programme is to generate and make available approximately 100 F1 progeny of mutagenised animals per week for genome-wide dominant phenotypic screens. Mice with aberrant phenotypes identified in any of the internal or collaborative phenotypic screens will be posted regularly on our website and will be made available to the scientific community.
German ENU Mutagenesis Program
Within our ENU Mutagenesis Project, we have established a research center to perform a large ENU mutagenesis screen in mouse. The research center consists of a core facility ( GSF , Gene Center ) and several associated laboratories (located at the TU Munich ; LMU Munich ; GSF , MPI of Biochemistry, Martinsried ; MPI of Psychiatry, Martinsried ; Clinic of the Univ. Freiburg ); University Utrecht . The core facility generates mutagenized F1 and G3 mice which are analyzed by the associated laboratories.
Mouse Mutagenesis for Developmental Defects
The goal of project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations
NHMRC Australian PhenomeBank
This project is producing and screening large libraries of mutagenized C57BL/6 or TCR transgenic mice to identify genes controlling the immune response.
McLaughlin Research Institute
Chemical mutagenesis is a powerful tool for functional annotation of the mouse genome sequence. A collaborative three-generation screen for recessive ENU-induced neurological and behavioral mutations is underway. In addition, individual scientists run smaller scale sensitized or targeted screens for mutations affecting pathways of neurodegeneration, prion disease, hearing, ear and kidney development, or peripheral myelination.
Riken Large Scale Mutagenesis Project
Our objective is to develop and establish a large number of mouse mutants that will be used for the "phenotype-driven" approach. The ultimate goals are to produce as many as mutants encompassing the whole mouse genome for providing resources to study the functions of genes, and to develop animal models for human diseases.
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Outlines NIDA’s drug abuse and addiction research strategic priorities for the next 5 years, focusing on prevention, treatment, HIV/AIDS, and other cross-cutting issues.