External link, please review our disclaimer.

Medical Consequences of Drug Abuse

Gastrointenstinal Effects

Mel Smith is a popular, university-educated actor and comedian who started taking the painkiller, Nurofen Plus (12mg of codeine/tablet)-- and taking, as many as 50 tablets a day. Taking these kinds of drugs to excess can lead to gastrointestinal problems, inflammation of the stomach, chronic constipation, abdominal bloating and liver damage. The habit landed Smith in a hospital with two burst stomach ulcers.

Source: Scotsman.com

Among other adverse effects, many drugs of abuse have been known to cause nausea and vomiting soon after use. Cocaine use can also cause abdominal pain.