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The Neurobiology of Drug Addiction

3: Localization of cocaine "binding sites"

Localization of cocaine binding sites

When a person smokes or snorts cocaine, it reaches all areas of the brain, but it binds to sites in some very specific areas. These are highlighted with the yellow dots: the VTA, the nucleus accumbens, and the caudate nucleus (the largest structure). Point out that cocaine binds especially in the reward areas that you have just discussed. The binding of cocaine in other areas such as the caudate nucleus can explain other effects such as increased stereotypic (or repetitive) behaviors (pacing, nail-biting, scratching, etc..)

This page was last updated January 2007

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National Institute on Drug Abuse (2007). 3: Localization of cocaine "binding sites". In The Neurobiology of Drug Addiction. Retrieved from http://www.drugabuse.gov/publications/teaching-packets/neurobiology-drug-addiction/section-iv-action-cocaine/3-localization-cocaine-binding-sites

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Explores the consequences of drug abuse on the brain and body and introduces the topics of prevention, and treatment.