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The Brain & the Actions of Cocaine, Opiates, and Marijuana

3: Cocaine binding to uptake pumps: inhibition of dopamine uptake

Cocaine binding to uptake pumps

Now, show what happens when cocaine is present in the synapse. Cocaine (turquoise) binds to the uptake pumps and prevents them from removing dopamine from the synapse. This results in more dopamine in the synapse, and more dopamine receptors are activated.

This page was last updated January 2007

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National Institute on Drug Abuse (2007). 3: Cocaine binding to uptake pumps: inhibition of dopamine uptake. In The Brain & the Actions of Cocaine, Opiates, and Marijuana. Retrieved from http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-opiates-marijuana/section-iii-introduction-to-drugs-abuse-cocaine-opiat-2

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Explores the consequences of drug abuse on the brain and body and introduces the topics of prevention, and treatment.