Is it safe to use opioid drugs with other medications?
Only under a physician's supervision can opioids be used safely with other drugs. Typically, they should not be used with other substances that depress the CNS, such as alcohol, antihistamines, barbiturates, benzodiazepines, or general anesthetics, because these combinations increase the risk of life-threatening respiratory depression.
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AP style citation
National Institute on Drug Abuse (2011). Is it safe to use opioid drugs with other medications?. In Prescription Drug Abuse. Retrieved from http://www.drugabuse.gov/publications/research-reports/prescription-drugs/opioids/it-safe-to-use-opioid-drugs-other-medications
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