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Addiction Science: From Molecules to Managed Care

Nearly all drugs of abuse increase dopamine neurotransmission.

Effects of Drugs on Dopamine release, showing dopamine spikes from amphetmine, cocaine, nicotine and morphine

This slide shows the increase in brain dopamine (DA) levels (measured in animals) following exposure to various drugs of abuse. All of the drugs depicted in this slide have different mechanisms of action, however they all increase activity in the brain reward pathway by increasing dopamine neurotransmission. It is because drugs activate these brain regions—usually more effectively and for longer periods of time than natural rewards—that they have an inherent risk of being abused.

This page was last updated July 2008

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National Institute on Drug Abuse (July 1 2008). Nearly all drugs of abuse increase dopamine neurotransmission.. In Addiction Science: From Molecules to Managed Care. Retrieved from http://www.drugabuse.gov/publications/addiction-science/why-do-people-abuse-drugs/nearly-all-drugs-abuse-increase-dopamine-neurotransmission

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