Brain pathways are affected by drugs of abuse.
The dopamine and serotonin pathways are two brain systems affected by drugs of abuse. They are illustrated here. By altering activity in these pathways, abused substances can influence their function. Dopamine neurons (shown in yellow) influence pleasure, motivation, motor function and saliency of stimuli or events. Serotonin (shown in red) plays a role in learning, memory, sleep and mood.
Attention
Due to the lapse in government funding, the information on this web site may not be up to date, transactions submitted via the web site may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. Updates regarding government operating status and resumption of normal operations can be found at
Looking for Treatment?
Use the SAMHSA Treatment Locator or 1-800-662-HELP.
Helpline open during government shutdown
Featured Publication
Drugs, Brains, and Behavior - The Science of Addiction
As a result of scientific research, we know that addiction is a disease that affects both brain and behavior.
Ordering Publications
Call 1-877-643-2644 or:
