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Addiction Science: From Molecules to Managed Care

Genome wide analyses are being used to identify novel candidate genes that increase the risk for addiction.

Gene cluster is associated with nicotine dependence

This image illustrates convergent findings from different laboratories identifiying a cluster of three nicotinic receptor subunit genes (α3 α5 β4) linked to smoking quantity, nicotine dependence, and the risk of two smoking-related diseases — lung cancer and peripheral arterial disease. This new information on genetic vulnerability also suggests novel targets for the development of medications to treat tobacco addiction and related diseases.

This page was last updated July 2008