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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Prenatal Methamphetamine Exposure Linked With Problems (December 2012)

Study findings indicate that children exposed to methamphetamine prenatally show more signs of increased emotionality, anxiety, and depression than nonexposed children at ages 3 and 5 years.

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Animation: Building an Anti-Drug Vaccine (December 2012)

The immune system has an extraordinary ability to recognize compounds foreign to the body and eliminate them. NIDA-sponsored scientists are working to harness this ability to create vaccines that will protect individuals against the psychogenic and addictive effects of abused drugs. This animation shows one of the most promising strategies, which has already yielded partial success in producing effective vaccines against nicotine, cocaine, and other drugs.

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Stress Receptor Mediates Lifelong Consequences of Early Trauma (November 2012)

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

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Good Behavior Game Wins 2012 Mentor International Best Practice Award (November 2012)

The NIDA-supported Good Behavior Game recently was honored with the 2012 Mentor International Best Practice Award. The game, which focuses on reducing disruptive behaviors in elementary school classrooms, has been shown to prevent drug abuse and other problems in adolescence and young adulthood.

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Dr. Charles O’Brien Receives the James B. Isaacson Award for Lifetime Achievement (November 2012)

NIDA researcher Dr. Charles O’Brien recently received the James B. Isaacson Award for a lifetime of research on the biological basis of alcoholism.

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Q&A: Dr. David Thomas (November 2012)

NIDA Program Officer Dr. David Thomas speaks about the intertwined problems of pain and prescription opioid abuse, as well as the research supported by NIDA and the National Institutes of Health to address these problems.

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Animal Research Advances Effort to Develop Vaccines Against Cocaine, Heroin Abuse (September 2012)

New vaccines that aim to promote recovery from cocaine and heroin abuse showed promise in animal testing. Both vaccines induced rats’ immune system to produce high titers of antibodies that inhibit the target drug from reaching the brain. The rats’ behaviors when given access to the target drug indicated that the vaccines reduced the reinforcing effects that, in recovering people, can cause lapses to turn into relapses.

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Potential Pain Medication Targets Peripheral Nerves (September 2012)

Researchers report a significant advance in the search for medications that can suppress pain but avoid opioids’ abuse potential and other undesirable CNS effects. A new compound reduces mouse responses in animal models of neurogenic and chronic inflammatory (e.g., arthritic) pain. The compound, called UB937, enhances the natural pain-killing activity of the neurotransmitter anandamide, and exerts its analgesic effects entirely in peripheral tissues, without entering the brain.

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Few Teens With Prescription Opioid Use Disorders Receive Treatment (July 2012)

Fewer than 12 percent of adolescents who meet diagnostic criteria for prescription opioid abuse or dependence receive any treatment, according to an analysis of data from the 2005 to 2008 National Survey on Drug Use and Health. The most common reason the adolescents gave for not receiving treatment was their lack of perceived need for it.

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Intervention Boosts Treatment Participation, Abstinence Among Depressed Women (July 2012)

Intensive case management was more effective in increasing treatment engagement and reducing alcohol consumption among depressed participants than among those who were not depressed, according to a followup analysis of a substance abuse treatment study involving women on welfare.

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