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NIDA Notes

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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Epigenetics: The Promise of a New Science (March 2008)

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

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Bupropion Reduces Meth's Subjective Effects and Cue-Induced Craving (March 2008)

Describes a study investigating the use of the antidepressant bupropion as a potential therapy for methamphetamine addiction.

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Chromosome 17 Harbors Opioid Dependence Genes (March 2008)

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Teen Substance Abuse Continues to Decline (March 2008)

Reports on the prevalence of substance abuse among youth based on 2007 data from a national survey of behaviors, attitudes, and values.

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Not All Mesolimbic Dopamine Neurons Are Alike (March 2008)

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Alcohol Abuse Makes Prescription Drug Abuse More Likely (March 2008)

Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

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Cocaine Can Mobilize Stored Dopamine (March 2008)

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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Chronic Cocaine Abusers Have Occult Insomnia in Early Abstinence (March 2008)

Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.

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HIV Patients Show Better Immune Recovery With Early Initiation of HAART (March 2008)

Presents evidence that among men and women with HIV, those who received early initiation of HAART therapy, those with higher CD4+ levels, achieved better immune recovery.

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Researchers Report on Progress of NIDA's Southern Africa Initiative (March 2008)

Presents an update on NIDA’s Southern African Initiative, a program that aims to build research capacity and infrastructure in the area of addiction, particularly drug-related HIV transmission.

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