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NIDA Notes

image of a brain scan
A prison with an arrow pointing down reading cost and another image of a treatment center with an arrow  pointing up and reading savings
A young Native American mother is playing with her child.
Schematic of the impact of methamphetamine and stress on signal transmission across synapses.

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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Scientific Society Honors Dr. Kenner Rice's Research (March 2008)

Announces the 2007 Smissman Award from the American Chemical Society to Dr. Kenner Rice, NIDA, for significant contributions to fundamental knowledge in medicinal chemistry.

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Sertraline Does Not Help Methamphetamine Abusers Quit (March 2008)

Describes a new research finding indicating that the antidepressant sertraline (Zoloft), prescribed to relieve depression during the methamphetamine withdrawal process, may make quitting harder.

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Epigenetics: The Promise of a New Science (March 2008)

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

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Bupropion Reduces Meth's Subjective Effects and Cue-Induced Craving (March 2008)

Describes a study investigating the use of the antidepressant bupropion as a potential therapy for methamphetamine addiction.

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Chromosome 17 Harbors Opioid Dependence Genes (March 2008)

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Teen Substance Abuse Continues to Decline (March 2008)

Reports on the prevalence of substance abuse among youth based on 2007 data from a national survey of behaviors, attitudes, and values.

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Not All Mesolimbic Dopamine Neurons Are Alike (March 2008)

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Alcohol Abuse Makes Prescription Drug Abuse More Likely (March 2008)

Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

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Cocaine Can Mobilize Stored Dopamine (March 2008)

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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Chronic Cocaine Abusers Have Occult Insomnia in Early Abstinence (March 2008)

Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.

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