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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Receptor Complexes Link Dopamine to Long-Term Neuronal Effects (October 2009)

Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

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Combined Treatments Improve Dual Abstinence (October 2009)

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

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Intervention for Disruptive Children Shows Long-Term Benefits (October 2009)

Reports on research providing evidence that teaching aggressive youngsters social coping skills reduces their chances of becoming substance abusers.

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Smoking and Drinking Continue to Decline, But Marijuana Stalls in Latest MTF Survey (October 2009)

Highlights trends from a 2008 survey of teenage substance abuse, cigarette smoking and alcohol use and discusses the implications of these changing data.

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NIDA Reprises Online Chat Day (October 2009)

Highlights NIDA’s second annual Chat Day where NIDA scientists and staff responded to drug abuse and addiction questions from teachers and students.

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Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize (October 2009)

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers (October 2009)

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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Manic Mice Show Heightened Sensitivity to Rewards (October 2009)

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

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Lower Rates of Cigarette and Marijuana Smoking Among Exercising Teens (October 2009)

Highlights prevalence rates of cigarette and marijuana smoking among teens who exercise regularly as compared with their less active peers.

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Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing (April 2009)

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

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