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NIDA Notes Articles

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Abstinent Patients Continue to Show Benefits of Treatment

April 2007
Reports on data that reviewing the benefits of addiction treatment among abstinent men as compared with those who continued to abuse cocaine.

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Antipsychotic Drug Prevents Morphine Tolerance in Mice

April 2007
Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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Depot Naltrexone Appears Safe and Effective for Heroin Addiction

April 2007
Presents results of a pilot study to investigate the safety and efficacy of a new long-lasting injectable formulation of naltrexone to treat of heroin addiction in an outpatient setting.

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Uneven Regional Brain Development Contributes to Adolescent Risk-Taking

April 2007

Reports on the work of scientists who have linked impulsiveness and risk-taking among adolescents to immaturity of the brain region called the orbitofrontal cortex.

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Incentives Reduce Stimulant Abuse During Methadone Maintenance

April 2007

Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

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Serotonin System May Have Potential as a Target for Cocaine Medications

April 2007
Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

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Genes and Smoking

April 2007

Reports on the research underway to identify gene variations associated with nicotine addiction and the interaction of genetic makeup, experiences, and surroundings to addiction.

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Nicotine Alters the Developing Rat Brain

February 2007
Describes animal studies that suggested exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

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Medical Care During Addiction Treatment Reduces Hospital Use

February 2007
Reports on an analysis comparing three types of addiction treatment programs: methadone maintenance programs, long-term residential programs, and nonmethadone programs.

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Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

February 2007
Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

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