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NIDA Notes Articles

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Study Links Anabolic Steroids to Brain Changes in Adolescent Female Mice

October 2007
Reports on an animal study finding that links anabolic steroids to brain changes in adolescent female mice, changes that can potentially lead to steroid abuse.

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Impacts of Drugs on Neurotransmission

October 2007

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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Depot Naltrexone Appears Safe and Effective for Heroin Addiction

April 2007
Presents results of a pilot study to investigate the safety and efficacy of a new long-lasting injectable formulation of naltrexone to treat of heroin addiction in an outpatient setting.

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Uneven Regional Brain Development Contributes to Adolescent Risk-Taking

April 2007

Reports on the work of scientists who have linked impulsiveness and risk-taking among adolescents to immaturity of the brain region called the orbitofrontal cortex.

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Incentives Reduce Stimulant Abuse During Methadone Maintenance

April 2007

Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

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Serotonin System May Have Potential as a Target for Cocaine Medications

April 2007
Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

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Genes and Smoking

April 2007

Reports on the research underway to identify gene variations associated with nicotine addiction and the interaction of genetic makeup, experiences, and surroundings to addiction.

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Vaccine May Reduce Fetal Exposure to Nicotine

April 2007
Describes research on a vaccine developed to facilitate smoking cessation by blocking nicotine penetration into the brain.

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Naltrexone-Nicotine Patch Combination Shows Promise

April 2007
Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

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Meeting Reviews Progress On Prescription Opioid Misuse

April 2007
Describes a meeting of researchers and clinicians who gathered to discuss the challenges in balancing appropriate pain treatment with efforts to minimize prescription opioid misuse.

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