NIDA Notes Articles: Genetics

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In Animals, Receptor Puts Brakes on Nicotine Consumption

March 2012
New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

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Individual Differences in Decisionmaking Style May Predict Teen Problems

December 2011
Reports on the relative influence of genes versus environment on adolescents’ choices that involve delayed gratification.

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Gene Influences Impact of Maternal Smoking on Children's Behavioral Problems

July 2011
Describes research showing that the combination of prenatal smoking exposure and specific genes increases children’s and adolescent’s risk for behavior problems.

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Parental Supervision and Genetics Interact To Influence Nicotine Addiction

December 2010
Reviews research indicating that both parental influence and certain genes interact to influence nicotine addiction and that parental monitoring may play a role in reducing risk.

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NIDA Grantee Wins Prize for Genetics Web Sites

December 2010
Announces the recipient of an award for online resources in education, Dr. Louisa Stark, who developed two interactive Web sites on genetics.

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Three Scientists Join Advisory Council

December 2010
Announces three new NIDA National Advisory Council on Drug Abuse members and describes their drug abuse and addiction research experience.

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Workgroup Directs Search for Genes That Influence Addiction

April 2010
Highlights NIDA’s research portfolio to identify the genes and genetic processes responsible for a person’s vulnerability to drug abuse.

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Genetic Overlap Between Substance Abuse and Bipolar Disorder

April 2010
Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

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Studies Link Family of Genes to Nicotine Addiction

December 2009
Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

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NIDA's 35th Anniversary: Science Focused on Solutions

December 2009
Commemorates NIDA’s 35th anniversary and highlights some of the major accomplishments since the Institute’s inception in 1974.

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