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NIDA Notes Articles: Addiction Science

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Morphine-Induced Immunosuppression, From Brain to Spleen

June 2008
Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

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Animal Studies Elaborate Toluene's Effects

June 2008
Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

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Reduced Longevity Among Male Heroin Abusers, 1962-1997

June 2008
Reviews the changing lifespan of heroin abusers as compared with that of the general U.S. population based on 1962-1997 data.

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Not All Mesolimbic Dopamine Neurons Are Alike

March 2008
Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Long-Term Cocaine Abuse Linked With Impaired Heart Function

March 2008
Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

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Alcohol Abuse Makes Prescription Drug Abuse More Likely

March 2008
Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

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Cocaine Can Mobilize Stored Dopamine

March 2008
Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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Epigenetics: The Promise of a New Science

March 2008

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

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Researchers Develop a New Tracer for Cannabinoid Receptor

March 2008
Describes a new chemical tracer that binds specifically to cannabinoid receptors making it potentially useful in future research to clarify the relationship between the receptors and drug abuse.

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NIDA Will Contribute to Obesity Research

October 2007

Describes an NIH-wide obesity task force and research plan and explores some of the links between addiction and compulsive eating.

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