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NIDA Notes Articles: Genetics

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Male Rats’ Cocaine Exposure Affects Their Offspring’s Drug Responses

August 2013

In a surprising finding, male rats who used cocaine sired male offspring who later exhibited blunted responses to the drug. Researchers determined the cause was an epigenetic alteration.

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Manic Mice Show Heightened Sensitivity to Rewards

October 2009

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

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Mice With Genetic Alteration Eschew Cocaine

June 2008

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

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New Technique Links 89 Genes to Drug Dependence

September 2008

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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NIDA Grantee Wins Prize for Genetics Web Sites

December 2010
Announces the recipient of an award for online resources in education, Dr. Louisa Stark, who developed two interactive Web sites on genetics.

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NIDA's 35th Anniversary: Science Focused on Solutions

December 2009

Commemorates NIDA’s 35th anniversary and highlights some of the major accomplishments since the Institute’s inception in 1974.

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Parental Supervision and Genetics Interact To Influence Nicotine Addiction

December 2010

Reviews research indicating that both parental influence and certain genes interact to influence nicotine addiction and that parental monitoring may play a role in reducing risk.

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PhenX Toolkit Provides Standard Measures for Research

July 2012
NIDA researchers working with human subjects now have a new resource at their fingertips: the PhenX Toolkit’s new Substance Abuse and Addiction (SAA) Collection. The Toolkit is designed to provide standardized measures, vetted and approved by the field, to help researchers compare and combine data from multiple studies.

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Resting Brain Studies Shed New Light on Vulnerabilities

November 2011

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

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Smokers Who Quit May Have Genetic Advantage

November 2009

Describes research providing evidence that genes may influence how successful a person is in quitting smoking and which cessation technique may work best for them.

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