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NIDA Notes Articles: Comorbidity

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Most People Entering Drug Treatment Have Additional Mental Health Problems

November 2009

Highlights data on the prevalence of people entering substance abuse treatment programs who also reported having at least one co-occurring mental health problem.

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Methylphenidate for Comorbid Cocaine Abuse, ADHD

October 2006
Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

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Manic Mice Show Heightened Sensitivity to Rewards

October 2009

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

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Low Dopamine Receptor Availability May Promote Cocaine Addiction

April 2009

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

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Intervention Boosts Treatment Participation, Abstinence Among Depressed Women

July 2012
Intensive case management was more effective in increasing treatment engagement and reducing alcohol consumption among depressed participants than among those who were not depressed, according to a followup analysis of a substance abuse treatment study involving women on welfare.

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HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis

January 2014

Study patients with HIV­­–hepatitis C coinfection progressed to successive degrees of severity of liver fibrosis 9 years sooner than those infected with HCV alone. Further findings from the study suggest that suppressing HIV with antiretroviral medications may slow HCV-related liver fibrosis.

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Helping Doctors Become First Responders to Substance Abuse

April 2010

Describes a toolkit that guides doctors in assessing a patient’s risk of developing an addiction problem, advising patients on the effects of substance abuse, and arranging for referrals.

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Genetic Overlap Between Substance Abuse and Bipolar Disorder

April 2010

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

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Dr. Kathleen T. Brady Recognized

October 2010
Recognizes the 2010 Distinguished University Professor awardee, Dr. Kathleen T. Brady, who studies co-occurring substance abuse and mental health disorders and their treatment.

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DESPR Identifies Drug Abuse Trends and Seeks Solutions

November 2009
Discusses the work of NIDA’s Division of Epidemiology, Services and Prevention Research, organized to track drug use and provide empirically based information for researchers and service providers.

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